Results 91 to 100 of about 932,452 (224)

Unlocking the potential of purinergic signaling in transplantation [PDF]

, 2016
Purinergic signaling has been recognized as playing an important role in inflammation, angiogenesis, malignancy, diabetes and neural transmission.
Robson, Simon C., Zeiser, Robert, Burnstock, Geoffrey, Dworak, M, Dworak, Markus, Zeiser, R, Burnstock, G, Vaikunthanathan, T., Vaikunthanathan, T, Robson, SC   +9 more
core   +1 more source

Impact of sleep insufficiency and recovery on cancer development

Sleep Research, EarlyView.
Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley   +1 more source

Purinergic signalling in B cells

Acta Biochimica Polonica, 2018
Adenosine and adenosine triphosphate are involved in purinergic signalling which plays important role in control of immune system. Much data have been obtained regarding impact of purinergic signalling on dendritic cells, macrophages, monocytes and T lymphocytes, however less attention has been paid to purinergic regulation of B cells.
Przybyła, Tomasz, Monika Sakowicz-Burkiewicz, Tadeusz Pawełczyk   +2 more
openaire   +3 more sources

Purinergic signaling in the immune system [PDF]

Autonomic Neuroscience, 2015
Extracellular ATP and its metabolite adenosine are increasingly recognized as key mediators of the immune response. Depending on the concentration, ATP may act as an immunostimulant or an immunodepressant, while adenosine is generally acknowledged to be a potent immunosupressor molecule. Signals delivered by extracellular ATP and adenosine are detected
DI VIRGILIO, Francesco, VUERICH, Marta
openaire   +3 more sources

Role of astrocyte purinergic signaling in epilepsy

, 2019
International audienceEpilepsy is characterized by unpredictable recurrent seizures resulting from hypersynchronous discharges from neuron assemblies. Increasing evidence indicates that aberrant astrocyte signaling to neurons plays an important role in ...
Nobili, Paola, Paola Nobili, Nikolic, Ljiljana, Shen, Weida, Weida Shen, Audinat, Etienne, Ljiljana Nikolic, Etienne Audinat   +7 more
core   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

The involvement of purinergic signalling in obesity [PDF]

Purinergic Signalling, 2018
Obesity is a growing worldwide health problem, with an alarming increasing prevalence in developed countries, caused by a dysregulation of energy balance. Currently, no wholly successful pharmacological treatments are available for obesity and related adverse consequences.
Geoffrey Burnstock, Daniela Gentile
openaire   +4 more sources

Purinergic Dysfunction in Pulmonary Arterial Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Pulmonary arterial hypertension (PAH) is a life‐threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, which result in an increase in afterload imposed onto the right ventricle, leading to right ...
Zongye Cai, Ly Tu, Christophe Guignabert, Daphne Merkus, Zhichao Zhou   +4 more
doaj   +1 more source