Results 111 to 120 of about 246,268 (219)
Extracellular Creatine Kinase May Modulate Purinergic Signalling
, 2019 It is proposed that cytosolic creatine kinase (CK) released to the extracellular space physiologically or after tissue damage modulates extracellular purinergic signalling. CK catalyses the rapid transfer of ADP into ATP. Extracellular purine nucleotides
Lizzy M. Brewster (782872)
core +1 more source
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source
Purinergic signalling between axons and microglia
, 2006 Neurons are delicate elements unable to withstand prolonged exposure to the many toxic factors that gain access to the CNS or which are made by activated leukocytes.
DI VIRGILIO, Francesco
core +1 more source
Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen +7 more
wiley +1 more source
, 2020 © 2016, Springer Science+Business Media Dordrecht.Extracellular ATP is suspected to contribute to migraine pain but regulatory mechanisms controlling pro-nociceptive purinergic mechanisms in the meninges remain unknown.
Yegutkin G. +8 more
core
Purinergic signalling in the pancreas in health and disease
, 2012 Pancreatic cells contain specialised stores for ATP. Purinergic receptors (P2 and P1) and ecto-nucleotidases are expressed in both endocrine and exocrine calls, as well as in stromal cells.
Novak, I, Burnstock, G
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Purinergic signaling in Alzheimer’s disease
Brain Research Bulletin, 2019 Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by three major histopathological markers: amyloid-β (Aβ) plaques, neurofibrillary tangles and gliosis in the central nervous system (CNS). It is now accepted that neuroinflammatory events in the CNS play a crucial role in the development of AD.
Laurie Erb +3 more
openaire +2 more sources
Purinergic Signalling in Physiology and Pathophysiology. [PDF]
Int J Mol Sci, 2023 Sluyter R.
europepmc +1 more source
Glia, Volume 74, Issue 11, November 2026.Relapsing colitis region‐specific microglial states beyond remission. Cortical microglia remain pro‐inflammatory and synapse‐disruptive, while hippocampal microglia shift toward a reparative program that maintains neuronal circuit stability. ABSTRACT Ulcerative colitis (UC) patients experience cycles of active gut inflammation and remission, with ...
Lorena Morton +6 more
wiley +1 more source