Results 121 to 130 of about 5,354,149 (260)

Modeling the lung‒brain axis in critical illness: Multifactorial crosstalk through organoids and organ‐on‐a‐chip system

VIEW, EarlyView.
Patients in intensive care units often experience lung injuries, complicated by brain problems. Advanced laboratory tools, organoids, and organs‐on‐chips facilitated the study of multiorgan interactions, help us understand the communication between the lungs and brain.
Wanyi Zhang, Ting Wang, Mengying Yao, Longxiang Su, Lixin Xie, Pan Pan   +5 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

ALS: Focus on purinergic signalling

Pharmacology & Therapeutics, 2011
Amyotrophic lateral sclerosis (ALS) is one of the most common neuromuscular diseases. It is devastating and fatal, causing progressive paralysis of all voluntary muscles and eventually death, while sparing cognitive functions. A pathological hallmark of ALS is neuroinflammation mediated by non-neuronal cells in the nervous system, such as microglia and
Volonté C. 1, 1, Apolloni S. 12, Carrì M.T. 2, 3, D'Ambrosi N. 1, 2   +6 more
openaire   +6 more sources

Differences in localization of P2X7 during epithelial wound healing in pre-type II diabetic models [PDF]

, 2017
Corneal injury, accompanied by improper wound repair, is the 4th highest cause of preventable blindness according to the World Health Organization.
Kneer, Krisandra
core  

Cannabinoid receptors contribute to astroglial Ca2+-signalling and control of synaptic plasticity in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is thought to be very important for many brain functions. Acting via release of gliotransmitters, astrocytes can modulate synaptic strength.
Lalo, Ulyana, Palygin, Oleg, Pankratov, Yuriy, Rasooli-Nejad, Seyed   +3 more
core   +1 more source

Human brain matters: Navigating the neuropathology of COVID‐19

Brain Pathology, EarlyView.
Severe COVID‐19 is associated with vascular dysregulation and chronic neuroinflammation, leading to axonal injury and neurodegeneration. In long COVID or PASC, persistent alterations in neuroimaging and biofluid biomarkers reflect ongoing neuronal damage and neuroinflammation, contributing to long‐term neurological symptoms including fatigue, cognitive
Juliana M. Nieuwland, Angelica Scaramuzza, Marianna Bugiani, Wilma D. J. van de Berg, Jinte Middeldorp   +4 more
wiley   +1 more source

Age-related changes in afferent pathways and urothelial function in the male mouse bladder [PDF]

, 2013
Key points •The prevalence of bladder conditions such as overactive bladder syndrome and urinary incontinence significantly increases with age, but how bladder function is altered by ageing is unclear.
Christopher Chapple, Chuang Y‐C, David Grundy, Donna M. Daly, Linda Nocchi, Marina Liaskos, Mohammed HA, Neil G. McKay   +7 more
core   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation

Human Molecular Genetics, 2016
Hypomorphic mutations in the gene encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme, ALPL in human or Akp2 in mice, cause hypophosphatasia (HPP), an inherited metabolic bone disease also characterized by spontaneous seizures.
Á. Sebastián‐Serrano, T. Engel, Laura de Diego-García, L. Olivos-Oré, Marina Arribas-Blázquez, Carlos Martínez-Frailes, Carmen Pérez-Díaz, J. Millán, A. R. Artalejo, M. Miras-Portugal, D. Henshall, M. Diaz-hernandez   +11 more
semanticscholar   +1 more source

P2X7 receptors induce degranulation in human mast cells. [PDF]

, 2016
Mast cells play important roles in host defence against pathogens, as well as being a key effector cell in diseases with an allergic basis such as asthma and an increasing list of other chronic inflammatory conditions.
A Lundequist, A Surprenant, AG Driver, AM Gilfillan, AS Kirshenbaum, AW Hauswirth, B Hechler, C Feng, CE Owen, D Ferrari, DM Manthei, E Shigetomi, Elizabeth P. Seward, ES Schulman, F Jacob, F Virgilio Di, G Barbara, G Buell, G Burnstock, G Burnstock, H Saito, J Capite Di, JM Brown, JP Bennett, K Mulryan, K Wareham, Kathryn J. Wareham, M Idzko, M Idzko, M Vig, MA McCloskey, MG Rolf, N Sudo, OK Basoglu, PE Tatham, R Dahlquist, R Dahlquist, RC Wykes, RJ Evans, SR Holdsworth, TM Egan, Y Kurashima, Y Osipchuk, ZG Gao   +43 more
core   +1 more source