Results 121 to 130 of about 246,268 (219)

Editorial: Purinergic signalling - a perspective from China. [PDF]

Purinergic Signal, 2023
Tang Y, Chen JF, Illes P.
europepmc   +1 more source

Tumor‐Regional Immune Microenvironment: A Critical Factor in the Design of Radiotherapy–Immunotherapy Combination Trials

International Journal of Cancer, Volume 159, Issue 8, Page 1857-1872, 15 October 2026.
ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang, Hui Wang, Weiyan Tang, Kai Kang, Kateryna Onyshchenko, Taotao Huang, Dan Liu, Jianxin Xue, You Lu, Gabriele Niedermann, Ren Luo   +10 more
wiley   +1 more source

Purinergic signalling in the genito-urinary tract. [PDF]

, 2006
The main objective of this thesis was to examine the role of purinergic signalling in the contraction of the smooth muscle of the genito-urinary tract of laboratory animals and compare it to that of man.
Banks, F.C.L.
core  

Gabapentinoids‐duloxetine combination therapy for chronic pain: A mechanism oriented rational to bridge theoretical knowledge and real life setting

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3333-3353, October 2026.
Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili, Maurizio Evangelista, Elena Lucarini, Elena G. Giugliano, Carla Ghelardini, Laura Micheli, Lorenzo Di Cesare Mannelli   +6 more
wiley   +1 more source

Editorial: Special issue on purinergic signalling and calcification. [PDF]

Purinergic Signal, 2023
Orriss IR, Arnett TR.
europepmc   +1 more source

ER Stress Regulates HIV Tat and Alcohol‐Induced NLRP6 Activation in Astrocytes

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
HIV Tat and ethanol synergistically induce ER stress in astrocytes, activating an ER stress‐NLRP6 inflammasome axis that drives caspase‐1 activation and IL‐1β/IL‐18 release. Targeting ER stress or NLRP6 effectively suppresses astrocytic neuroinflammation, identifying a novel therapeutic pathway for alcohol‐exacerbated NeuroHIV.
Seema Singh, Elias Horanieh, Shilpa Buch, Palsamy Periyasamy   +3 more
wiley   +1 more source

Immune cells in the pathogenesis of abdominal aortic aneurysm: Roles, regulation and targeted interventions

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
This review provides a comprehensive overview of how macrophages, neutrophils, T cells and other immune cells infiltrate the aortic wall, undergo phenotypic shifts and interact with one another in abdominal aortic aneurysm (AAA). Background Abdominal aortic aneurysm (AAA) is a lethal degenerative vascular disease with no approved clinical drugs. Immune
Junqi Peng, Hanqing Zhang, Yun Wu, Song Chen   +3 more
wiley   +1 more source

Kainate-induced ATP release contributes to spinal excitotoxicity that is attenuated by purinergic blockade

Frontiers in Neurology
IntroductionSevere spinal cord injury (SCI) is characterized by irreversible neuronal loss and permanent motor/sensory dysfunction with very limited treatment.
Benjamín Zylberberg, Benjamín Zylberberg, M. Florencia Coronel, M. Florencia Coronel, Graciela L. Mazzone, Graciela L. Mazzone   +5 more
doaj   +1 more source

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Glia, Volume 74, Issue 10, October 2026.
CX3CR1 deficiency promotes microglial migration toward CNS injury. Proteomic profiling reveals altered RHO‐mediated cytoskeletal signaling, while in vivo two‐photon imaging demonstrates increased process extension, velocity, and accumulation of Cx3cr1‐deficient microglia at lesion sites. ABSTRACT Microglia are innate immune cells of the central nervous
Jens Wagner, Henrike Antony, Cornelia Hoyer, Kristiina Lundgrén, Rabah Soliymani, Sophie Crux, Lena Justus, Kevin Keppler, Julia Steffen, Christian Kurts, Daniel R. Engel, Jochen Herms, Maciej Łałowski, Martin Fuhrmann   +13 more
wiley   +1 more source

Purinergic signalling in skin

, 2002
Purinergic receptors, which bind ATP, are expressed on human cutaneous keratinocytes. Previous work in rat epidermis suggested functional roles of purinergic receptors in the regulation of proliferation, differentiation and apoptosis, for example P2X5 ...
Greig, Aina V. H.
core