Results 141 to 150 of about 7,573 (248)

Beyond the surface: P2Y receptor downstream pathways, TLR crosstalk and therapeutic implications for infection and autoimmunity

Pharmacological Research
A successful immune response must effectively obtain pathogen clearance upon infection while preventing excessive collateral tissue damage. It is therefore essential to achieve a nuanced fine regulation of pro- and anti-inflammatory signals to ...
Lena Rueschpler, Sebastian Schloer
doaj   +1 more source

Exploration of the link between gut microbiota and purinergic signalling. [PDF]

Purinergic Signal, 2023
Li M, Liu B, Li R, Yang P, Leng P, Huang Y.   +5 more
europepmc   +1 more source

Microbial Metabolite‐Stimulated Bitter Taste Receptor T2R14 Signaling Is Modulated by CFTR Interactions

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Bitter taste receptors (T2Rs) play an important role in physiological and cellular responses. Bitter tasting chemicals and microbial metabolites can bind to T2R14, which enables interactions between T2R14 and specific intracellular domains of the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel.
Tejas Gupte, Nisha Singh, Vikram Bhatia, Kavisha Arora, Shayan Amiri, Paul Fernyhough, Anjaparavanda P. Naren, Shyamala Dakshinamurti, Prashen Chelikani   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

[Purinergic signals].

Medicina, 2010
In the last decade evidence accumulated that nucleosides and nucleotides of both uridine and adenine can act as extracellular signaling factors. Their action is mediated by two main types of surface receptors commonly known as purinergic. P1 receptors are metabotropic and activated by adenosine, whereas receptors for nucleotides (ATP, ADP, UTP and UDP)
Eduardo R, Lazarowski, Pablo J, Schwarzbaum   +1 more
openaire   +1 more source

Purinergic signalling : from normal behaviour to pathological brain function

, 2011
Purinergic neurotransmission, involving release of ATP as an efferent neurotransmitter was first proposed in 1972. Later, ATP was recognised as a cotransmitter in peripheral nerves and more recently as a cotransmitter with glutamate, noradrenaline, GABA,
Peter Illes, G. Burnstock, Geoffrey Burnstock, M.P. Abbracchio, P. Illes, Ute Krügel, U. Krügel, Maria P. Abbracchio   +7 more
core   +1 more source

A Novel Catalytically Inactive Construct of Botulinum Neurotoxin A (BoNT/A) Directly Inhibits Visceral Sensory Signalling

Toxins
Botulinum neurotoxin A (BoNT/A) is a potent neurotoxin that silences cholinergic neurotransmission through the cleavage of the synaptic protein SNAP-25.
Hodan Ibrahim, Kevin Retailleau, Fraser Hornby, Jacquie Maignel, Matthew Beard, Donna Marie Daly   +5 more
doaj   +1 more source

MicroRNA: Crucial modulator in purinergic signalling involved diseases. [PDF]

Purinergic Signal, 2023
Guo J, Yang P, Li YF, Tang JF, He ZX, Yu SG, Yin HY.   +6 more
europepmc   +1 more source

Purinergic signalling in the nervous system: an overview

, 2009
Purinergic receptors, represented by several families, are arguably the most abundant receptors in living organisms and appeared early in evolution. After slow acceptance, purinergic signalling in both peripheral and central nervous systems is a rapidly ...
G. Burnstock, Burnstock, Geoffrey, Zimmermann, Herbert, Geoffrey Burnstock, H. Zimmermann, M.P. Abbracchio, A. Verkhratsky, Herbert Zimmermann, Abbracchio, Maria P., Verkhratsky, Alexei; id_orcid, Alexei Verkhratsky, Maria P. Abbracchio   +11 more
core   +1 more source

Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik, Kay Jüngling, Sven G. Meuth, Thomas Budde, Marta Méndez‐Couz   +4 more
wiley   +1 more source