Results 161 to 170 of about 7,573 (248)

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Purinergic signalling in the cardiovascular system-a tribute to Geoffrey Burnstock. [PDF]

Purinergic Signal, 2021
Ralevic V.
europepmc   +1 more source

Synergistic Effect of Hesperidin, Acarbose, and Exercise Combination on Neuroinflammation and Neurochemical Alterations in Diabetic Encephalopathy Rat Model

Food Chemistry International, Volume 2, Issue 2, Page 263-273, June 2026.
Diabetic encephalopathy (DME) impairs neurobehavior, neurochemicals, oxidative stress, and inflammation. This study evaluated the effects of hesperidin (HSP), exercise (EX), and acarbose (ACA) alone or combined on diabetic rats. Treatments reduced AChE, BChE, ACE, arginase, ATPDase, 5′‐nucleotidase, ADA, LDH, TBARS, and ROS, while increasing IL‐10, SOD,
Idowu Sunday Oyeleye, Olajide Raymond Ojo, Taiwo Olawale Adeleke, Adeyinka Sunday Ajeigbe, Mercy Gladys Tenywa, Oboh Ganiyu   +5 more
wiley   +1 more source

A novel definition and treatment of hyperinflammation in COVID-19 based on purinergic signalling. [PDF]

Purinergic Signal, 2022
Hasan D, Shono A, van Kalken CK, van der Spek PJ, Krenning EP, Kotani T.   +5 more
europepmc   +1 more source

Purinergic signalling in dictyostelium discoideum

, 2009
The identification of five predicted proteins (dP2XA-E) with homology to vertebrate P2X receptors in Dictyostelium discoideum proved a unique opportunity to explore purinergic receptor function in a simple unicellular eukaryote from outside the animal ...
Melanie Joanna Ludlow (7590974)
core  

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants

Glia, Volume 74, Issue 6, June 2026.
Zebrafish pde6c mutants undergo photoreceptor degeneration from 5 dpf, but rods regenerate from 4 wpf. scRNA‐seq of retinal microglia reveals dynamic change of states between 5 dpf and 4 wpf. Two states emerge specifically during regeneration. ABSTRACT Microglia, brain‐resident immune cells, maintain brain homeostasis.
Darshini Ravishankar, Yuki Takeuchi, Ichiro Masai   +2 more
wiley   +1 more source

An introduction to the special issue "The contribution of pannexin-1, connexins and CALHM ATP-release channels to purinergic signalling". [PDF]

Purinergic Signal, 2021
Kennedy C.
europepmc   +1 more source

Purinergic Signalling in Allogeneic Haematopoietic Stem Cell Transplantation and Graft-versus-Host Disease. [PDF]

Int J Mol Sci, 2021
Cuthbertson P, Geraghty NJ, Adhikary SR, Bird KM, Fuller SJ, Watson D, Sluyter R.   +6 more
europepmc   +1 more source

Cannabidiol Protects Against 1‐Methyl‐4‐Phenylpyridinium and Manganese‐Induced Neurotoxicity via Nod‐Like Receptor Protein 3 Inflammasome Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
CBD oil exhibits neuroprotective effects in Parkinson's disease models by inhibiting NLRP3 inflammasome activation. It preserves dopamine levels and reduces α‐synuclein accumulation, suggesting its potential as a therapeutic strategy against neuroinflammation and neurodegeneration.
Göksun Demirel, Anıl Yirün, Deniz Arca Çakir, Hüseyin Özkan, Berfu Şura Güneş, Selen Selvi, Yeter EROL. Öztürk, Pınar Erkekoğlu   +7 more
wiley   +1 more source

Investigating Purinergic Signalling in Chondrocytes [PDF]

Chondrocytes are the sole cell type in cartilage and are highly specialised to produce the cartilaginous extracellular matrix that gives rise to unique biochemical properties facilitating joint movement.
Saffer, Daniel
core