Results 171 to 180 of about 7,573 (248)

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Encephalopathy: Cause, Pathogenesis, and Treatment

MedComm, Volume 7, Issue 6, June 2026.
Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv, Xia Zhong, Ruirui Shang, Linghui Kong, Yufei Huang, Yuexiang Ma, Jing Teng, Sheng Wei   +7 more
wiley   +1 more source

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, Volume 45, Issue 5, Page 929-936, June 2026.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Two G protein-coupled receptors bind ceramides in atherosclerosis progression: targets for a new therapeutic strategy

Signal Transduction and Targeted Therapy
Yue Han, Peter Illes, Yong Tang
doaj   +1 more source

Special Issue "Purinergic Signalling in Physiology and Pathophysiology 2.0". [PDF]

Int J Mol Sci
Sluyter R.
europepmc   +1 more source

Clopidogrel, an ADP‐P2Y12 Receptor Antagonist, Is Associated With Lower Opioid Consumption and a Reduced Incidence of Delirium in Cancer Patients Receiving Chemotherapy: A Nationwide Retrospective Cohort Study in Japan

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Clopidogrel use was associated with reduced opioid consumption, lower use of other analgesics, and a decreased incidence of hyperactive delirium compared with aspirin in cancer patients receiving chemotherapy, suggesting a potential analgesic effect possibly linked to P2Y12 receptor inhibition.
Hiroaki Abe, Reo Inoue, Takamichi Kogure, Rikuhei Tsuchida, Hiroaki Owada, Yoshika Sudo, Yaeko Yokoshima, Hiroki Matsui, Hideo Yasunaga, Masahiko Sumitani   +9 more
wiley   +1 more source

Editorial: “Purinergic Signaling 2020: The State-of-The-Art Commented by the Members of the Italian Purine Club”

Frontiers in Pharmacology, 2021
Francisco Ciruela, Francisco Ciruela, Kjell Fuxe, Peter Illes, Peter Illes, Henning Ulrich, Henning Ulrich, Francesco Caciagli   +7 more
doaj   +1 more source

Editorial: Purinergic signalling-a perspective from China (II). [PDF]

Purinergic Signal
Tang Y, Illes P.
europepmc   +1 more source

The role of the bladder urothelium as a chemical-neural transducer via purinergic signalling in the rapid defence against bacterial infection. [PDF]

Purinergic Signal, 2021
Chakrabarty B.
europepmc   +1 more source

THE IMPACT OF PURINERGIC SIGNALLING IN RENAL ISCHAEMIA-REPERFUSION INJURY

, 2008
THE IMPACT OF PURINERGIC SIGNALLING IN RENAL ISCHAEMIA-REPERFUSION ...
A d'Apice (13612609), E Lee (13296936), S Crikis (13612123), B Lu (7864358), S Rajakumar (19214518), P Cowan (2892578), S Robson (12638098), K Dwyer (14541254)   +7 more
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