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Correction to: The analgesic effect of electroacupuncture in alleviating paclitaxel-induced peripheral neuropathic pain and its possible mechanism relates to TLR4/P2X7-NLRP3 signaling pathway. [PDF]
Purinergic SignalZhou YX +5 more
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Purinergic signalling in osteoblasts
Frontiers in Bioscience, 2012 The skeleton is maintained throughout life via the finely tuned actions of osteoblasts and osteoclasts, with disruption in this balance eventually leading to bone disease. The exact mechanisms balancing these actions are not fully known, although several
Alison Gartland +2 more
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Purinergic Signalling and Neurological Diseases: An Update [PDF]
CNS and Neurological Disorders - Drug Targets, 2017 Purinergic signalling, i.e. ATP as an extracellular signalling molecule and cotransmitter in both peripheral and central neurons, is involved in the physiology of neurotransmission and neuromodulation.
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Purinergic Signaling in the Airways
Pharmacological Reviews, 2012Evidence for a significant role and impact of purinergic signaling in normal and diseased airways is now beyond dispute. The present review intends to provide the current state of knowledge of the involvement of purinergic pathways in the upper and lower airways and lungs, thereby differentiating the involvement of different tissues, such as the ...
Burnstock, Geoffrey +3 more
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Purinergic signaling and microglia
Pflügers Archiv - European Journal of Physiology, 2006Microglial cells are considered as the pathologic sensors of the brain. In this paper, we review mechanisms of purinergic signaling in microglia. As ATP is not only considered as a physiological signaling substance but is also elevated in pathology, it is not surprising that microglia express a variety of P2X, P2Y and adenosin receptors.
Katrin, Färber, Helmut, Kettenmann
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Purinergic signaling in atherosclerosis
Trends in Molecular Medicine, 2015Cell surface expression of specific receptors and ecto-nucleotidases makes extracellular nucleotides such as ATP, ADP, UTP, and adenosine suitable as signaling molecules for physiological and pathological events, including tissue stress and damage.
FERRARI, Davide +3 more
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Glycogenolysis and Purinergic Signaling
2014Both ATP and glutamate are on one hand essential metabolites in brain and on the other serve a signaling function as transmitters. However, there is the major difference that the flux in the pathway producing transmitter glutamate is comparable to the rate of glucose metabolism in brain, whereas that producing transmitter ATP is orders of magnitude ...
Leif, Hertz, Junnan, Xu, Liang, Peng
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Brain Research Reviews, 2010
A growing body of evidence indicates that extracellular nucleotides play important roles in the regulation of neuronal and glial functions in the nervous system through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y).
Makoto, Tsuda +2 more
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A growing body of evidence indicates that extracellular nucleotides play important roles in the regulation of neuronal and glial functions in the nervous system through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y).
Makoto, Tsuda +2 more
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Purinergic Signalling and the Nervous System
, 2012 In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed ...
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Purinergic signaling in thyroid disease
Purinergic Signalling, 2022It is known that thyroid hormones play pivotal roles in a wide variety of pathological and physiological events. Thyroid diseases, mainly including hyperthyroidism, hypothyroidism, and thyroid cancer, are highly prevalent worldwide health problems and frequently associated with severe clinical manifestations.
Ying Le, Donghui Lu, Meng Xue
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