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Purinergic signaling and microglia
Pflügers Archiv - European Journal of Physiology, 2006Microglial cells are considered as the pathologic sensors of the brain. In this paper, we review mechanisms of purinergic signaling in microglia. As ATP is not only considered as a physiological signaling substance but is also elevated in pathology, it is not surprising that microglia express a variety of P2X, P2Y and adenosin receptors.
Katrin Färber, Helmut Kettenmann
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Journal of Fish Diseases, 2018
Extracellular adenosine triphosphate (ATP) and its metabolite adenosine (Ado) are recognized as key mediators of immune and inflammatory responses. Depending on its concentration, ATP may act as an immunostimulant or immunodepressant, while Ado levels ...
M. Baldissera +6 more
semanticscholar +1 more source
Extracellular adenosine triphosphate (ATP) and its metabolite adenosine (Ado) are recognized as key mediators of immune and inflammatory responses. Depending on its concentration, ATP may act as an immunostimulant or immunodepressant, while Ado levels ...
M. Baldissera +6 more
semanticscholar +1 more source
Brain Research Reviews, 2010
A growing body of evidence indicates that extracellular nucleotides play important roles in the regulation of neuronal and glial functions in the nervous system through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y).
Makoto Tsuda +2 more
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A growing body of evidence indicates that extracellular nucleotides play important roles in the regulation of neuronal and glial functions in the nervous system through P2 purinoceptors. P2 purinoceptors are divided into two families, ionotropic receptors (P2X) and metabotropic receptors (P2Y).
Makoto Tsuda +2 more
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Glycogenolysis and Purinergic Signaling
2014Both ATP and glutamate are on one hand essential metabolites in brain and on the other serve a signaling function as transmitters. However, there is the major difference that the flux in the pathway producing transmitter glutamate is comparable to the rate of glucose metabolism in brain, whereas that producing transmitter ATP is orders of magnitude ...
Junnan Xu, Leif Hertz, Liang Peng
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Purinergic Signaling in Glioma Progression
2012Among the pathological alterations that give tumor cells invasive potential, purinergic signaling is emerging as an important component. Studies performed in in vitro, in vivo and ex vivo glioma models indicate that alterations in the purinergic signaling are involved in the progression of these tumors.
Ana Maria Oliveira Battastini +3 more
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Signaling at Purinergic P2X Receptors
Annual Review of Physiology, 2009P2X receptors are membrane cation channels gated by extracellular ATP. Seven P2X receptor subunits (P2X1-7) are widely distributed in excitable and nonexcitable cells of vertebrates. They play key roles in inter alia afferent signaling (including pain), regulation of renal blood flow, vascular endothelium, and inflammatory responses.
Surprenant, Annmarie, Alan North, R.
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Introduction to Purinergic Signaling
2019Purinergic signaling was proposed in 1972, after it was demonstrated that adenosine 5'-triphosphate (ATP) was a transmitter in nonadrenergic, noncholinergic inhibitory nerves supplying the guinea-pig taenia coli. Later, ATP was identified as an excitatory cotransmitter in sympathetic and parasympathetic nerves, and it is now apparent that ATP acts as a
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Extracellular ATP and P2 purinergic signalling in the tumour microenvironment
Nature Reviews. Cancer, 2018F. Di Virgilio +4 more
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Purinergic signaling in peripheral nervous system glial cells
Glia, 2021Jennifer Patritti-cram +2 more
exaly
2012
Publisher Summary Purines such as ATP and adenosine play a central role in the energy metabolism of all life forms. This fact probably delayed recognition of other roles for purines as autocrine and paracrine substances, and neurotransmitters. The principal ligands for purinergic receptors are adenosine, ATP and UTP.
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Publisher Summary Purines such as ATP and adenosine play a central role in the energy metabolism of all life forms. This fact probably delayed recognition of other roles for purines as autocrine and paracrine substances, and neurotransmitters. The principal ligands for purinergic receptors are adenosine, ATP and UTP.
openaire +2 more sources