Results 31 to 40 of about 99,040 (285)

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

Cell Reports, 2017
Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang, Adi Zheng, Per Hydbring, Gorbatchev Ambroise, Amanda Tomie Ouchida, Michel Goiny, Helin Vakifahmetoglu-Norberg, Erik Norberg   +7 more
doaj   +1 more source

Transiently Transfected Purine Biosynthetic Enzymes Form Stress Bodies [PDF]

, 2013
It has been hypothesized that components of enzymatic pathways might organize into intracellular assemblies to improve their catalytic efficiency or lead to coordinate regulation.
Cook, Lindsey, Ellington, Andrew D., Marcotte, Edward M., Swaminathan, Jagannath, Tsechansky, Mark, Zhao, Alice   +5 more
core   +8 more sources

Teores de proteína bruta para bovinos alimentados com feno de capim-tifton 85: parâmetros ruminais, eficiência de síntese microbiana e degradabilidade in situ Effects of crude protein levels on microbial efficiency and in situ degradability in steers fed Tifton 85 bermudagrass hay supplemented with different protein sources

Revista Brasileira de Zootecnia, 2007
Avaliou-se o efeito da deficiência de PB na dieta sobre a eficiência de síntese microbiana e a degradabilidade in situ da MS e FDN em novilhos mestiços.
Edilane Aparecida da Silva, Telma Teresinha Berchielli, Ricardo Andrade Reis, Alexandre Vaz Pires, Kátia Junko Sato, José Mauro Valente Paes, André Dias Lopes   +6 more
doaj   +1 more source

The changes in purine metabolism in gastric cancer

Gastroenterologìa, 2019
Background. Gastric cancer (GC) is considered an urgent problem of oncology, due to its high incidence and morta­lity, diagnosis at a later stage of the disease progression, anatomical and topographical features of the organ affected by the tumor and the
O.V. Syniachenko, R.F. Aliiev, M.V. Iermolaieva, V.G. Bondar   +3 more
doaj   +1 more source

Metabolomic and transcriptomic response to imatinib treatment of gastrointestinal stromal tumour in xenograft-bearing mice

Translational Oncology, 2023
Background: Although imatinib is a well-established first-line drug for treating a vast majority of gastrointestinal stromal tumours (GIST), GISTs acquire secondary resistance during therapy.
Szymon Macioszek, Danuta Dudzik, Rafał Bartoszewski, Tomasz Stokowy, Diether Lambrechts, Bram Boeckx, Agnieszka Wozniak, Patrick Schöffski, Michał J. Markuszewski   +8 more
doaj   +1 more source

Partial (13)C isotopic enrichment of nucleoside monophosphates: useful reporters for NMR structural studies [PDF]

, 2005
Analysis of the (13)C isotopic labeling patterns of nucleoside monophosphates (NMPs) extracted from Escherichia coli grown in a mixture of C-1 and C-2 glucose is presented. By comparing our results to previous observations on amino acids grown in similar
Kishore, Anita I., Mayer, Michael R., Prestegard, James H.   +2 more
core   +2 more sources

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Cells
Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the ...
Corey S. Worledge, Rachael E. Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P. Colgan, J. Scott Lee   +5 more
doaj   +1 more source

Novel Point-of-Care Diagnostic Method for Neonatal Encephalopathy Using Purine Nucleosides

Frontiers in Molecular Neuroscience, 2021
Background: Evidence suggests that earlier diagnosis and initiation of treatment immediately after birth is critical for improved neurodevelopmental outcomes following neonatal encephalopathy (NE). Current diagnostic tests are, however, mainly restricted
Edward Beamer, Edward Beamer, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Mary Isabel O’Dea, Aisling A. Garvey, Aisling A. Garvey, Jonathon Smith, Jonathon Smith, Aida Menéndez-Méndez, Lynne Kelly, Lynne Kelly, Andreea Pavel, Andreea Pavel, Sean Quinlan, Mariana Alves, Eva M. Jimenez-Mateos, Faming Tian, Eugene Dempsey, Eugene Dempsey, Nicholas Dale, Deirdre M. Murray, Deirdre M. Murray, Geraldine B. Boylan, Geraldine B. Boylan, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Eleanor J. Molloy, Tobias Engel, Tobias Engel   +31 more
doaj   +1 more source

A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]

, 2015
Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum, Blackburn, Gavin, Daskalaki, Evangelia, Kalna, Gabriela, Watson, David, Zhang, Tong   +5 more
core   +2 more sources

Benzoxazine–Purine Hybrids as Antiproliferative Agents: Rational Design and Divergent Mechanisms of Action

Pharmaceutics
Background/Objectives: Targeted cancer therapies increasingly rely on modulating specific cell death pathways and kinase signaling. Due to their structural versatility and potential to induce mechanistically distinct cytotoxic responses, benzoxazine ...
Houria Boulaiz, Yaiza Jiménez-Martínez, Francisco Franco-Montalbán, Jesús Peña-Martín, Ana Conejo-García, M. Dora Carrión   +5 more
doaj   +1 more source