Results 31 to 40 of about 53,051 (335)

Basis for the control of purine biosynthesis by purine ribonucleotides. [PDF]

Journal of Clinical Investigation, 1981
An animal model was used to determine the basis for the increase in purine biosynthesis that results from hepatic depletion of purine nucleotides, such as seen in patients with type I glycogen storage disease or following fructose administration. Mice were injected intravenously with glucose or fructose, 2.5 mg/g of body weight, and the animals were ...
Edward W. Holmes, Richard L. Sabina, Mitsuo Itakura, Peter W. Heald   +3 more
openaire   +3 more sources

P2X7 Receptor Upregulation in Huntington’s Disease Brains

Frontiers in Molecular Neuroscience, 2020
Huntington’s disease (HD) is a fatal degenerative disorder affecting the nervous system. It is characterized by motor, cognitive, and psychiatric dysfunctions, with a late onset and an autosomal dominant pattern of inheritance.
Ivana Ollà, Ivana Ollà, María Santos-Galindo, María Santos-Galindo, Ainara Elorza, Ainara Elorza, José J. Lucas, José J. Lucas   +7 more
doaj   +1 more source

Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis

Cells
Inflammatory bowel disease (IBD) is marked by a state of chronic energy deficiency that limits gut tissue wound healing. This energy shortfall is partially due to microbiota dysbiosis, resulting in the loss of microbiota-derived metabolites, which the ...
Corey S. Worledge, Rachael E. Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P. Colgan, J. Scott Lee   +5 more
doaj   +1 more source

Synthesis of Pyridinium Moiety Containing Triazolyl Purines

Molbank
Pyridinium salts of 2-piperidinyl-6-triazolylpurine derivatives were obtained by the introduction of pyridinium moieties into the propane-1,3-diol fragment at the N(9) position of purine to enhance the solubility of 2-amino-6-triazolylpurine derivatives ...
Aleksejs Burcevs, Māris Turks, Irina Novosjolova   +2 more
doaj   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Modifiable nutritional factors in hyperuricemia and gout

Alʹmanah Kliničeskoj Mediciny, 2022
Uric acid is an independent risk factor for socially important diseases, such as chronic heart failure and chronic kidney disease. The review summarizes current data on the impact of nutrition as a presumably modifiable factor into the development of ...
Olga A. Georginova, Polina N. Astashkevich, Tatyana N. Krasnova   +2 more
doaj   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Oligonucleotides Featuring a Covalently Mercurated 6‐Phenylcarbazole Residue as High‐Affinity Hybridization Probes for Thiopyrimidine‐Containing Sequences

Chemistry – A European Journal, Volume 28, Issue 69, December 9, 2022., 2022
Getting back to (nucleo)base: Oligonucleotides incorporating a central 1‐ or 8‐mercuri‐6‐phenyl‐1H‐carbazole residue show great promise as high‐affinity hybridization probes, discriminating between all canonical nucleobases as well as 2‐ and 4‐thiothymines by melting temperature margins of at least 5 °C.
Tharun K. Kotammagari, Petri Tähtinen, Tuomas Lönnberg   +2 more
wiley   +1 more source

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine

Nanomaterials, 2023
Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski   +6 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source