Results 51 to 60 of about 99,040 (285)
Linear model for fast background subtraction in oligonucleotide microarrays [PDF]
, 2009 One important preprocessing step in the analysis of microarray data is background subtraction. In high-density oligonucleotide arrays this is recognized as a crucial step for the global performance of the data analysis from raw intensities to expression ...
Barkema, Gerard T. +2 more
core +4 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Revista Brasileira de Zootecnia, 2010 Objetivou-se analisar a variação do pH, da amônia ruminal e do balanço de compostos nitrogenados e a síntese de proteína microbiana de 12 vacas da raça Holandesa distribuídas em três quadrados latinos 4 × 4, alimentadas com dietas contendo soja em ...
Angela Maria de Vasconcelos +5 more
doaj +1 more source
Substituted Purines as High-Affinity Histamine H3 Receptor Ligands
Pharmaceuticals, 2022 Continuing with our program to obtain new histamine H3 receptor (H3R) ligands, in this work we present the synthesis, H3R affinity and in silico studies of a series of eight new synthetically accessible purine derivatives.
Christian Espinosa-Bustos +7 more
doaj +1 more source
The dynamics of single spike-evoked adenosine release in the cerebellum [PDF]
, 2010 The purine adenosine is a potent neuromodulator in the brain, with roles in a number of diverse physiological and pathological processes. Modulators such as adenosine are difficult to study as once released they have a diffuse action (which can affect ...
Beierlein +41 more
core +2 more sources
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
Purine Acquisition and Synthesis by Human Fungal Pathogens
Microorganisms, 2017 While members of the Kingdom Fungi are found across many of the world’s most hostile environments, only a limited number of species can thrive within the human host. The causative agents of the most common invasive fungal infections are Candida albicans,
Jessica L. Chitty, James A. Fraser
doaj +1 more source
Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma [PDF]
, 2021 Kaoru Onidani +14 more
openalex +1 more source
, 1974 The origin of life is in a sense a genetic problem, for, as H. J. Muller pointed out many years ago, the essential attribute that identifies living matter is its capacity to replicate itself and its variants (1). Because this uniquely biological property
Horowitz, N. H., Hubbard, Jerry S.
core +1 more source
Advanced Functional Materials, EarlyView.DNA strands are employed both as dynamic linkers and nanoscale templates for the integration of Ag2S nanoparticles on MoS2, which in turn imparted photothermal responsiveness; this feature permits the selective cargo (fluorophore, quantum dots or an enzyme) release from the MoS2 surface in response to local heat induced by light irradiation.
Kai Chen +3 more
wiley +1 more source