Results 51 to 60 of about 36,659 (205)
Glutamine Phosphoribosylpyrophosphate Amidotransferase-independent Phosphoribosyl Amine Synthesis from Ribose 5-Phosphate and Glutamine or Asparagine [PDF]
, 2007 Phosphoribosylamine (PRA) is the first intermediate in the common pathway to purines and thiamine and is generated in bacteria by glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase (EC 2.4.2.14) from PRPP and glutamine.
Downs, Diana M. +2 more
core +2 more sources
Autonomic Neuroscience, 2022 The story of purinergic neurotransmission and regulation is intimately linked to studies of the somatosensory system. Burnstock's contributions to the discovery of ATP as a primary afferent neurotransmitter, as well as a signal of peripheral tissue damage that depolarised sensory neurons initiated a new period of pain research.
openaire +4 more sources
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
Advanced Science, EarlyView.This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu +9 more
wiley +1 more source
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.ABSTRACT Schizophrenia is a neurodevelopmental psychiatric disorder characterized by symptoms of psychosis, thought disorder, and flattened affect. Immune mechanisms are associated with schizophrenia, though the precise nature of this relationship (causal, correlated, consequential) and the mechanisms involved are not fully understood.
David Stacey +6 more
wiley +1 more source
Absorption of pyrimidines, purines and nucleosides by Li, Na, Mg, and Ca montmorillonite /clay organic studies 12/ [PDF]
Absorption of purines, pyrimidines, and nucleoside in aqueous solution by montmorillionite occurring as cation exchange ...
Brindley, G. W. +2 more
core +1 more source
Infrared absorption spectra of a series of 2, 6-diamino and 2-amino-6hydroxy-8-choroalkyl purines [PDF]
, 2003 8-haloalky purines were synthesized and infrared analysis (IR) carried out on them. The syntheses as well as the ill analyses are reported. The purines synthesized and studied include (i) 2,6-diamin-8-Chloromethyl purines, (ii) 2, 6-diamin-8-chlorethyl
I. M., Ejimadu
core
Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]
, 2010 Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh +63 more
core +6 more sources
Animal Models and Experimental Medicine, EarlyView.Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani +6 more
wiley +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source