Results 51 to 60 of about 53,976 (309)

Teores de proteína bruta para bovinos alimentados com feno de capim-tifton 85: parâmetros ruminais, eficiência de síntese microbiana e degradabilidade in situ Effects of crude protein levels on microbial efficiency and in situ degradability in steers fed Tifton 85 bermudagrass hay supplemented with different protein sources

Revista Brasileira de Zootecnia, 2007
Avaliou-se o efeito da deficiência de PB na dieta sobre a eficiência de síntese microbiana e a degradabilidade in situ da MS e FDN em novilhos mestiços.
Edilane Aparecida da Silva, Telma Teresinha Berchielli, Ricardo Andrade Reis, Alexandre Vaz Pires, Kátia Junko Sato, José Mauro Valente Paes, André Dias Lopes   +6 more
doaj   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet   +11 more
wiley   +1 more source

P2X4 signalling contributes to hyperactivity but not pain sensitization comorbidity in a mouse model of attention deficit/hyperactivity disorder

Frontiers in Pharmacology
Introduction: Attention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by hyperactivity, inattention, and impulsivity that often persist until adulthood.
Sarah Bou Sader Nehme, Sarah Bou Sader Nehme, Sandra Sanchez-Sarasua, Sandra Sanchez-Sarasua, Ramy Adel, Marie Tuifua, Awatef Ali, Amina E. Essawy, Sherine Abdel Salam, Walid Hleihel, Eric Boué-Grabot, Marc Landry   +11 more
doaj   +1 more source

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Purine and carbohydrate availability drive Enterococcus faecalis fitness during wound and urinary tract infections

mBio
Enterococcus faecalis is commonly isolated from a variety of wound types. Despite its prevalence, the pathogenic mechanisms of E. faecalis during wound infection are poorly understood. Using a mouse wound infection model, we performed in vivo E. faecalis
Casandra Ai Zhu Tan, Kelvin Kian Long Chong, Daryl Yu Xuan Yeong, Celine Hui Min Ng, Muhammad Hafiz Ismail, Zhei Hwee Yap, Varnica Khetrapal, Vanessa Shi Yun Tay, Daniela I. Drautz-Moses, Yusuf Ali, Swaine L. Chen, Kimberly A. Kline   +11 more
doaj   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

Efficient Synthesis of Novel Triazolo[5,1-b]purines by Diacetoxyiodobenzene-Mediated Oxidative Cyclization of Schiff Bases

Reactions
In this work, we have developed a method for synthesizing new 8-substituted triazolo[5,1-b]purines using diacetoxyiodobenzene as an oxidizing agent with good yields (59–67%).
Artyom O. Neymash, Victor V. Fedotov, Evgeny N. Ulomsky, Daniil N. Lyapustin, Semen V. Aminov, Vladimir L. Rusinov   +5 more
doaj   +1 more source

DISORDERS OF PURIN METABOLISM [PDF]

Journal of the American Medical Association, 1912
The old time term "uric acid diathesis" was an elastic expression, embracing such different conditions as gout, chronic rheumatism, uratic calculus, obesity and certain nephritides. In the light of more recent knowledge, the meaning of the term has been gradually narrowed until at the present time it includes only those diseases or clinical syndromes ...
Alfred C. Reed, George B. Wallace
openaire   +3 more sources