Results 21 to 30 of about 10,772,524 (242)
Applied Microscopy, 2020 The cerebellum is a region of the brain that plays an important role in motor control. It is classified phylogenetically into archicerebellum, paleocerebellum and neocerebellum.
Hyun-Wook Kim +4 more
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Journal of Neuroinflammation, 2009 Background Immunoglobulin G (IgG) antibodies reactive with intracellular neuronal proteins have been described in paraneoplastic and other autoimmune disorders.
Rose John W +4 more
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Molecular Brain, 2009 Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa +4 more
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Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss. [PDF]
Front Mol Neurosci, 2023 Spinocerebellar ataxias (SCAs) are a group of hereditary neurodegenerative diseases mostly affecting cerebellar Purkinje cells caused by a wide variety of different mutations. One subtype, SCA14, is caused by mutations of Protein Kinase C gamma (PKCγ), the dominant PKC isoform present in Purkinje cells. Mutations in the pathway in which PKCγ is active,
Kapfhammer JP, Shimobayashi E.
europepmc +4 more sources
Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]
PLoS ONE, 2009 The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs +3 more
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The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. [PDF]
, 2016 The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing
Calton, Michele A +4 more
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Why do so many genetic insults lead to Purkinje Cell degeneration and spinocerebellar ataxia?
Neuroscience Letters, 2018 The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally diverse spinocerebellar ataxia genes have been identified.
Miaozhen Huang, D. Verbeek
semanticscholar +1 more source
The Purkinje cell; 2008 style [PDF]
Journal of Molecular and Cellular Cardiology, 2008 Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential.
Wen, Dun, Penelope A, Boyden
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Purkinje cell models: past, present and future. [PDF]
Front Comput NeurosciThe investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro EM +5 more
europepmc +6 more sources
Development of axon-target specificity of ponto-cerebellar afferents.
PLoS Biology, 2011 The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron
Anna Kalinovsky +6 more
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