Frontiers in Cellular Neuroscience, 2015 Genetically inherited mutations in the fibroblast growth factor 14 (FGF14) gene lead to spinocerebellar ataxia type 27 (SCA27), an autosomal dominant disorder characterized by heterogeneous motor and cognitive impairments.
F. Tempia +6 more
semanticscholar +1 more source
Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]
, 1995 To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel +2 more
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mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
core +2 more sources
The cerebellum could solve the motor error problem through error increase prediction [PDF]
, 2015 We present a cerebellar architecture with two main characteristics. The first one is that complex spikes respond to increases in sensory errors. The second one is that cerebellar modules associate particular contexts where errors have increased in the ...
O'Reilly, Randall C. +1 more
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Integration of Purkinje Cell Inhibition by Cerebellar Nucleo-Olivary Neurons
Journal of Neuroscience, 2015 Neurons in the cerebellar cortex, cerebellar nuclei, and inferior olive (IO) form a trisynaptic loop critical for motor learning. IO neurons excite Purkinje cells via climbing fibers and depress their parallel fiber inputs. Purkinje cells inhibit diverse
Marion Najac, I. Raman
semanticscholar +1 more source
Mouse model reveals the role of RERE in cerebellar foliation and the migration and maturation of Purkinje cells. [PDF]
PLoS ONE, 2014 Nuclear receptors and their coregulators play a critical role in brain development by regulating the spatiotemporal expression of their target genes.
Bum Jun Kim, Daryl A Scott
doaj +1 more source
The Effect of Different Forms of Synaptic Plasticity on Pattern Recognition in the Cerebellar Cortex [PDF]
, 2009 “The original publication is available at www.springerlink.com”. Copyright Springer.Many cerebellar learning theories assume that long-term depression (LTD) of synapses between parallel fibres (PFs) and Purkinje cells (PCs) provides the basis for pattern
Adams, R.G. +4 more
core +1 more source
The Journal of General Physiology, 1985 Microprocessor-controlled changes of [free Ca2+] at the outer surface of the sarcoplasmic reticulum (SR) wrapped around individual myofibrils of a skinned canine cardiac Purkinje cell and aequorin bioluminescence recording were used to study the ...
A. Fabiato
semanticscholar +1 more source
Brain Sciences, 2020 Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal development of Purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum.
Tara Barron, Jun Hee Kim
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Mitochondrial morphogenesis, dendrite development, and synapse formation in cerebellum require both Bcl-w and the glutamate receptor delta2. [PDF]
PLoS Genetics, 2008 Bcl-w belongs to the prosurvival group of the Bcl-2 family, while the glutamate receptor delta2 (Grid2) is an excitatory receptor that is specifically expressed in Purkinje cells, and required for Purkinje cell synapse formation.
Qiong A Liu, Helen Shio
doaj +1 more source