Results 81 to 90 of about 10,772,524 (242)

Trehalose alleviates the phenotype of Machado–Joseph disease mouse models [PDF]

, 2020
Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration.
Cavadas, Cláudia, Cunha-Santos, Janete, Gaspar, Laetitia S., Greif, Hagar, Nobre, Rui Jorge, Nóbrega, Clévio, Paixão, Susana, Pereira de Almeida, Luís, Santana, Magda M., Silva, Teresa Pereira, Trevino-Garcia, Allyson   +10 more
core   +1 more source

Purkinje Cell Pathology and Loss in Multiple Sclerosis Cerebellum

Brain Pathology, 2014
Cerebellar ataxia commonly occurs in multiple sclerosis, particularly in chronic progressive disease. Previous reports have highlighted both white matter and grey matter pathological changes within the cerebellum; and demyelination and inflammatory cell ...
J. Redondo, K. Kemp, Kelly Hares, C. Rice, N. Scolding, A. Wilkins   +5 more
semanticscholar   +1 more source

The Marr and Albus Theories of the Cerebellum: Two Eary Models of Associative Memory [PDF]

, 1989
The Marr and Albus theories of the cerebellum are compared and contrasted. They are shown to be similar in their analysis of the function of the mossy fibers, granule cells, Golgi cells, and Purkinje cells.
Albus, James S.
core   +1 more source

Purkinje cell input to cerebellar nuclei in tottering: Ultrastructure and physiology [PDF]

, 2008
Homozygous tottering mice are spontaneous ataxic mutants, which carry a mutation in the gene encoding the ion pore of the P/Q-type voltage-gated calcium channels.
A Pinto, AG Garcia, AH Heller, BE Fureman, BJ Kaplan, CF Fletcher, Chris I. De Zeeuw, CI Zeeuw De, CI Zeeuw De, D Hillman, DB Campbell, DB Campbell, DB Campbell, F Rossi, FE Hoebeek, Freek E. Hoebeek, GJ Stephens, H Meier, HH Goossens, IJ Rhyu, IM Mintz, J Baurle, J Heuser, JC Desclin, JL Noebels, JS Stahl, K Alvina, K Matsushita, K Sawada, K Takei, KG Sutton, KR Isaacs, Laurens Witter, LC Abbott, M Uusisaari, M Uusisaari, M Wakamori, M Womack, MC Green, MG Paulin, N Hirokawa, NC Rowland, O Caillard, P Monsivais, P Strata, RR Llinás, S Satake, Sara Khosrovani, T Ikemoto, TL Shirley, TM Teune, WA Catterall, YH Chung, ZM Khaliq   +53 more
core   +4 more sources

Infant and adult SCA13 mutations differentially affect Purkinje cell excitability, maturation, and viability in vivo

eLife, 2020
Mutations in KCNC3, which encodes the Kv3.3 K+ channel, cause spinocerebellar ataxia 13 (SCA13). SCA13 exists in distinct forms with onset in infancy or adulthood.
Jui-Yi Hsieh, Brittany N Ulrich, Fadi A Issa, Meng-chin A Lin, Brandon Brown, Diane M Papazian   +5 more
doaj   +1 more source

Cerebellar Learning in an Opponent Motor Controller for Adaptive Load Compensation and Synergy Formation [PDF]

, 1993
This paper shows how a minimal neural network model of the cerebellum may be embedded within a sensory-neuro-muscular control system that mimics known anatomy and physiology.
Bullock, Daniel, Contreras-Vidal, Jose L., Grossberg, Stephen   +2 more
core   +1 more source

Mild Cerebellar Neurodegeneration of Aged Heterozygous PCD Mice Increases Cell Fusion of Purkinje and Bone Marrow-Derived Cells

Cell Transplantation, 2012
Bone marrow-derived cells have different plastic properties, especially regarding cell fusion, which increases with time and is prompted by tissue injury.
David Díaz, Javier S. Recio, Eduardo Weruaga, Jose R. Alonso   +3 more
doaj   +1 more source

Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity

Journal of Neuroscience, 2014
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in
Shane A. Heiney, Jinsook Kim, G. Augustine, J. Medina   +3 more
semanticscholar   +1 more source

The Plasma Membrane Ca2+-ATPase2 (PMCA2) Is Involved in the Regulation of Purkinje Cell Dendritic Growth in Cerebellar Organotypic Slice Cultures

Neural Plasticity, 2013
Purkinje cells are the principal neurons of the cerebellar cortex and have an extensive and elaborate dendritic tree. Chronic activation of type I metabotropic glutamate receptors inhibits Purkinje cell dendritic growth in organotypic cerebellar slice ...
Pradeep Sherkhane, Josef P. Kapfhammer
doaj   +1 more source

Duration of complex-spikes grades Purkinje cell plasticity and cerebellar motor learning

Nature, 2014
Behavioural learning is mediated by cellular plasticity, such as changes in the strength of synapses at specific sites in neural circuits. The theory of cerebellar motor learning relies on movement errors signalled by climbing-fibre inputs to cause long ...
Yan Yang, S. Lisberger
semanticscholar   +1 more source