Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity [PDF]
Communications BiologyPurkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans.
Stefano Masoli +12 more
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The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. [PDF]
PLoS ONE, 2012 In vitro, cerebellar Purkinje cells can intrinsically fire action potentials in a repeating trimodal or bimodal pattern. The trimodal pattern consists of tonic spiking, bursting, and quiescence.
Michael D Forrest +3 more
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Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum [PDF]
CellsFetal alcohol spectrum disorders (FASD) caused by developmental ethanol exposure lead to cerebellar impairments, including motor problems, decreased cerebellar weight, and cell death.
MaKenna Y. Cealie +6 more
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Neural Development, 2010 Background Cerebellar corticogenesis begins with the assembly of Purkinje cells into the Purkinje plate (PP) by embryonic day 14.5 (E14.5) in mice. Although the dependence of PP formation on the secreted protein Reelin is well known and a prevailing ...
Miyata Takaki +7 more
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Ankfy1 Is Involved in the Maintenance of Cerebellar Purkinje Cells
Frontiers in Cellular Neuroscience, 2021 Purkinje cells are critical for the function of cerebellum. The degeneration of Purkinje cells leads to defects in motion control. We have found that Purkinje cells specifically express Ankfy1 protein during development and in adult.
Liansheng Chang +3 more
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Feedback inhibition underlies new computational functions of cerebellar interneurons
eLife, 2022 The function of a feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons (MLIs) was defined by combining optogenetics, neuronal activity recordings both in cerebellar slices and in vivo, and computational modeling.
Hunter E Halverson +4 more
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Patterned neuroprotection in the Inpp4a(wbl) mutant mouse cerebellum correlates with the expression of Eaat4. [PDF]
PLoS ONE, 2009 The weeble mutant mouse has a frame shift mutation in inositol polyphosphate 4-phosphatase type I (Inpp4a). The phenotype is characterized by an early onset cerebellar ataxia and neurodegeneration, especially apparent in the Purkinje cells. Purkinje cell
Andrew J Sachs +3 more
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Scientific Reports, 2021 Purkinje cells are critically involved in processing the cerebellar functions by shaping and coordinating commands that they receive. Here, we demonstrate experimentally that in the adult zebrafish valvular part of the cerebellum, the Purkinje cells ...
Weipang Chang +4 more
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Serotonin drives a novel GABAergic synaptic current recorded in rat cerebellar purkinje cells: a lugaro cell to Purkinje cell synapse [PDF]
, 2003 We recorded a novel fast GABAergic synaptic current in cerebellar Purkinje cells in rat brain slices using patch-clamp techniques. Because of a relatively low sensitivity to bicuculline, these currents can be recorded under conditions in which basket ...
Dean, I., Edwards, F.A., Robertson, S.J.
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Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons
eLife, 2021 Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden +8 more
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