Results 131 to 140 of about 82,652 (261)
A deep learning‐enabled toolkit for the 3D segmentation of ventricular cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend 3D cardiomyocyte segmentation enables comprehensive analyses of myocardial microstructure in health and disease; however, it is technically demanding. We present an open‐source toolkit for this task, which reduces challenges associated with sample preparation, image restoration, segmentation and proofreading.
Joachim Greiner +6 more
wiley +1 more source
On the mechanism of control of the pulse rate
Experimental Physiology, EarlyView.
Mark I. M. Noble +1 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Mitochondrial SK channel enhancement reduces cardiac arrhythmia trigger. Spontaneous sarcoplasmic reticulum (SR) Ca2+ release via hyperactive RyR2s underlies an increased arrhythmia trigger, promoting early and delayed afterdepolarizations during stress. Hyperactive RyR2s causes rise in cytosolic [Ca2+] during diastole. Clearance
Dmitry Terentyev +7 more
wiley +1 more source
Mesenchymal and neural stem cell differentiation into Purkinje-like cells: Morphological study
Journal of Taibah University Medical Sciencesالملخص: أهداف البحث: تُعدّ خلايا بيركنجي فئةً محورية من الخلايا العصبية المُثبِّطة في الجهاز العصبي المركزي، وقد ارتبطخلل وظيفتها بطيفٍ من الاضطرابات العصبية.
Maeda H. Mohammad, PhD +4 more
doaj +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstact figure legend A panoramic 3D optical mapping system was developed, enabling imaging of action potential waves across the entire strongly deforming ventricular surface of beating isolated hearts. The system comprises 12 high‐speed cameras and a soccerball‐shaped imaging chamber with 48 light‐emitting diodes (LEDs).
Shrey Chowdhary +5 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Activation time (AT) maps from right ventricular apical pacing in a human ventricles model with longer action potential duration in the His‐Purkinje system (HPS) than in the myocardium (MYO). For pacing with a long S1S2 coupling interval (CI), the AT from the myocardial pacing site to the first AT of the HPS (ATMYO) is longer ...
Jason D. Bayer +3 more
wiley +1 more source
Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan +6 more
wiley +1 more source