Results 151 to 160 of about 82,652 (261)

Uncertainty should be the rule, not the exception: Integrating fibre orientation variability in cardiac electrophysiology modelling

The Journal of Physiology, EarlyView.
Ovais Ahmed Jaffery, Caroline Helen Roney   +1 more
wiley   +1 more source

Neuronal Activity Promotes Node‐Like Cluster Assembly Prior to Myelination and Remyelination in the Central Nervous System

Glia, Volume 74, Issue 4, April 2026.
Ronzano et al. show that neuronal activity promotes node‐like cluster (NLC) formation before (re)myelination by regulating β1Nav and Nav1.1, which are essential for NLC assembly. This may represent an intermediate step in activity‐driven myelination and contribute to the regulation of axonal conduction.
Rémi Ronzano, Clément Perrot, Elisa Mazuir, Melina Thetiot, Marie‐Stéphane Aigrot, Paul Stheneur, François‐Xavier Lejeune, Bruno Stankoff, Catherine Lubetzki, Nathalie Sol‐Foulon, Anne Desmazières   +10 more
wiley   +1 more source

A neural language for the cerebellum: control of behavior via competing populations of Purkinje cells. [PDF]

J Neurophysiol
Shadmehr R, Fakharian MA.
europepmc   +1 more source

Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 4, April 2026.
The axon initial segment (AIS) is a specialized axonal domain critical for maintaining neuronal polarity, action potential initiation, and network stability. This review summarizes the necessary elements for maintaining AIS structure and plasticity, discussing crucial biological functions of AIS in neuronal signaling and the neural circuit homeostasis,
Dong‐Yan Song, Lin Yuan, Weiguo Yang, Wen Li, Jia‐Yi Li   +4 more
wiley   +1 more source

Developmental transformations of Purkinje cells tracked by DNA electrokinetic mobility. [PDF]

Cell Rep Methods
Brandenburg C, Crutcher GW, Romanowski AJ, Donofrio SG, Duraine LR, Owusu-Mensah RNA, Cooper BH, Sugihara I, Blatt GJ, Sillitoe RV, Poulopoulos A.   +10 more
europepmc   +1 more source

Exclusion of CLIC5 as a Candidate Gene and Identification of NEFM as a Possible Novel Gene Correlated With Autosomal Recessive Pure Cerebellar Ataxia in a Highly Consanguineous Family

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole‐exome sequencing candidate CLIC5 and NEFM for cerebellar ataxia (CA) onset. In vivo studies exclude CLIC5, while in silico analysis and literature review support NEFM as a candidate gene for CA. These findings could be useful for advancing the genetic diagnosis of hereditary pure CA. Created in https://BioRender.com.
Paolo Enrico Maltese, Gabriele Bonetti, Elena Manara, Benedetta Tanzi, Andrea Bernini, Mark A. Berryman, Soichi Tanda, Corinne Nielsen, Silvia Casagrande, Amanda Ferrero, Salvatore Stano, Riccardo Zuccarino, Andrea Barp, Pietro Chiurazzi, Matteo Bertelli   +14 more
wiley   +1 more source

The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells. [PDF]

Front Physiol
Masoli S, Rizza MF, Moccia F, D'Angelo E.   +3 more
europepmc   +1 more source

An Autopsy Case With Fragile X‐Associated Tremor/Ataxia Syndrome Presenting Intranuclear Inclusion Bodies Mainly in the Limbic System

Neuropathology, Volume 46, Issue 2, April 2026.
ABSTRACT Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder characterized by a late onset and slow progression caused by a premutation (55–200 CGG repeat) in the fragile X mental retardation (FMR1) gene. Here, we report the case of a Japanese patient with FXTAS which is the first case autopsied in Japan. The patient was
Ayako Shioya, Kazuhiro Ishii, Taiki Sato, Masayuki Noguchi, Akira Tamaoka, Yuko Saito   +5 more
wiley   +1 more source

Autonomous STING signaling in Purkinje cells drives neurodegeneration independent of type I interferon. [PDF]

Cell Rep
Yang K, Dunn M, Torres-Ramirez G, Dobbs N, Shakkottai VG, Yan N.   +5 more
europepmc   +1 more source

Testosterone modulates multispectral oscillatory activity serving performance of motor sequences in typically developing youth

The Journal of Physiology, Volume 604, Issue 7, Page 3114-3134, 1 April 2026.
Abstract figure legend Increases in testosterone are associated with developmental changes in motor‐related neural oscillations in youth. Abstract Motor control is critical to daily functioning and undergoes significant refinement throughout youth. Although the effects of age on the underlying brain circuitry have been well characterized, fewer studies
Jackson Derby, Thomas W. Ward, Nathan M. Petro, Jake J. Son, Grace C. Ende, Danielle L. Rice, Anna T. Coutant, Erica L. Steiner, Vince D. Calhoun, Yu‐Ping Wang, Julia M. Stephen, Elizabeth Heinrichs‐Graham, Tony W. Wilson   +12 more
wiley   +1 more source