Results 11 to 20 of about 10,727,728 (294)
Purkinje Cell Patterning—Insights from Single-Cell Sequencing
Cells, 2022 Despite their homogeneous appearance, Purkinje cells are remarkably diverse with respect to their molecular phenotypes, physiological properties, afferent and efferent connectivity, as well as their vulnerability to insults.
Elizabeth J. Apsley, Esther B. E. Becker
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Frontiers in Synaptic Neuroscience, 2019 Optogenetics is a state-of-the-art tool for interrogating neural circuits. In the cerebellum, Purkinje cells serve as the sole output of the cerebellar cortex where they synapse on neurons in the deep cerebellar nuclei (DCN).
Kim M. Gruver +2 more
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Aging of cerebellar Purkinje cells
Cell and Tissue Research, 2010 Cerebellar Purkinje cells (PCs), the sole output neurons in the cerebellar cortex, play an important role in the cerebellar circuit. PCs appear to be rather sensitive to aging, exhibiting significant changes in both morphology and function during ...
Changzheng Zhang, Qingfeng Zhu, T. Hua
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Disease Models & Mechanisms, 2018 Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje ...
Esra Tara +3 more
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Brain Sciences, 2020 Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal development of Purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum.
Tara Barron, Jun Hee Kim
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Encoding of error and learning to correct that error by the Purkinje cells of the cerebellum
Nature Neuroscience, 2018 The primary output cells of the cerebellar cortex, Purkinje cells, make kinematic predictions about ongoing movements via high-frequency simple spikes, but receive sensory error information about that movement via low-frequency complex spikes (CS).
David J. Herzfeld +3 more
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Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish
Behavioral and Brain Functions, 2012 Background Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje
Yoshida Masayuki, Kondo Hiroki
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The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. [PDF]
PLoS ONE, 2008 The adult cerebellar cortex is comprised of reproducible arrays of transverse zones and parasagittal stripes of Purkinje cells. Adult stripes are created through the perinatal rostrocaudal dispersion of embryonic Purkinje cell clusters, triggered by ...
Matt Larouche +3 more
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Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells
Scientific Reports, 2018 Purkinje cells receive synaptic input from several classes of interneurons. Here, we address the roles of inhibitory molecular layer interneurons in establishing Purkinje cell function in vivo.
A. M. Brown +9 more
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A Simplified Method for Generating Purkinje Cells from Human-Induced Pluripotent Stem Cells
Cerebellum, 2018 The establishment of a reliable model for the study of Purkinje cells in vitro is of particular importance, given their central role in cerebellar function and pathology.
L. Watson +4 more
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