Results 11 to 20 of about 82,652 (261)
Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons
eLife, 2021 Preterm infants that suffer cerebellar insults often develop motor disorders and cognitive difficulty. Excitatory granule cells, the most numerous neuron type in the brain, are especially vulnerable and likely instigate disease by impairing the function ...
Meike E van der Heijden +8 more
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Spiral-wave dynamics in a mathematical model of human ventricular tissue with myocytes and Purkinje fibers [PDF]
, 2017 We present systematic numerical studies of the possible effects of the coupling of human endocardial and Purkinje cells at cellular and two-dimensional tissue levels.
Nayak, Alok Ranjan +2 more
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Disease Models & Mechanisms, 2018 Many cerebellar-induced neurological disorders, such as ataxias and cerebellar-induced dystonias, are associated with abnormal Purkinje cell activity. In tottering mice, a well-established mouse model of episodic ataxia type 2 (EA2), cerebellar Purkinje ...
Esra Tara +3 more
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Fear conditioning-related changes in cerebellar Purkinje cell activities in goldfish
Behavioral and Brain Functions, 2012 Background Fear conditioning-induced changes in cerebellar Purkinje cell responses to a conditioned stimulus have been reported in rabbits. It has been suggested that synaptic long-term potentiation and the resulting increases in firing rates of Purkinje
Yoshida Masayuki, Kondo Hiroki
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The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum. [PDF]
PLoS ONE, 2008 The adult cerebellar cortex is comprised of reproducible arrays of transverse zones and parasagittal stripes of Purkinje cells. Adult stripes are created through the perinatal rostrocaudal dispersion of embryonic Purkinje cell clusters, triggered by ...
Matt Larouche +3 more
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Brain Sciences, 2020 Human cerebellar development occurs late in gestation and is hindered by preterm birth. The fetal development of Purkinje cells, the primary output cells of the cerebellar cortex, is crucial for the structure and function of the cerebellum.
Tara Barron, Jun Hee Kim
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The Purkinje cell; 2008 style [PDF]
Journal of Molecular and Cellular Cardiology, 2008 Cardiac Purkinje fibers, due to their unique anatomical location, cell structure and electrophysiologic characteristics, play an important role in cardiac conduction and arrhythmogenesis. Purkinje cell action potentials are longer than their ventricular counterpart, and display two levels of resting potential.
Wen, Dun, Penelope A, Boyden
openaire +2 more sources
Journal of Neuroinflammation, 2009 Background Immunoglobulin G (IgG) antibodies reactive with intracellular neuronal proteins have been described in paraneoplastic and other autoimmune disorders.
Rose John W +4 more
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Frontiers in Aging Neuroscience, 2022 MRE11, RAD50, and NBS1 form the MRN complex in response to DNA damage to activate ATM, a gene responsible for Ataxia-Telangiectasia (A-T). Loss of any components of the MRN complex compromises cell life.
Mingmei Ding +11 more
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The Cerebellum and SIDS: Disordered Breathing in a Mouse Model of Developmental Cerebellar Purkinje Cell Loss during Recovery from Hypercarbia. [PDF]
, 2016 The cerebellum assists coordination of somatomotor, respiratory, and autonomic actions. Purkinje cell alterations or loss appear in sudden infant death and sudden death in epilepsy victims, possibly contributing to the fatal event. We evaluated breathing
Calton, Michele A +4 more
core +2 more sources