Neurobiology of Disease, 2011 Alteration in mitochondrial dynamics has been implicated in many neurodegenerative diseases. Mitochondrial apoptosis inducing factor (AIF) plays a key role in multiple cellular and disease processes.
Seung-Hyuk Chung +4 more
doaj +1 more source
Cerebellar Cortex, Purkinje Cell Layer [PDF]
, 2008 This report contains a summary of expression patterns for genes that are enriched in the Purkinje cell layer (CBXpu) of the cerebellum. All data is derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project.
Allen Institute for Brain Science +3 more
core +2 more sources
Direct reprogramming of cardiomyocytes into cardiac Purkinje-like cells
iScience, 2022 Summary: Currently, there are no treatments that ameliorate cardiac cell death, the underlying basis of cardiovascular disease. An unexplored cell type in cardiac regeneration is cardiac Purkinje cells; specialized cells from the cardiac conduction ...
Nicole Prodan +11 more
doaj +1 more source
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior. [PDF]
, 2017 Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior.
Aksay, Emre RF +5 more
core +2 more sources
Analysis of Microstructure of the Cardiac Conduction System Based on Three-Dimensional Confocal Microscopy. [PDF]
PLoS ONE, 2016 The specialised conducting tissues present in the ventricles are responsible for the fast distribution of the electrical impulse from the atrio-ventricular node to regions in the subendocardial myocardium.
Daniel Romero +3 more
doaj +1 more source
Encoding of action by the Purkinje cells of the cerebellum
Nature, 2015 Execution of accurate eye movements depends critically on the cerebellum, suggesting that the major output neurons of the cerebellum, Purkinje cells, may predict motion of the eye.
David J. Herzfeld +3 more
semanticscholar +1 more source
mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors [PDF]
, 2018 In cerebellar Purkinje cells (PCs) type-1 metabotropic glutamate (mGlu1) receptors play a key role in motor learning and drive the refinement of synaptic innervation during postnatal development.
Atsu Aiba +16 more
core +2 more sources
Secretin facilitates GABA transmission in the cerebellum [PDF]
, 2001 Secretin was the first hormone discovered in human history, and yet, its function as a neuropeptide has been overlooked in the past. The recent discovery of the potential use of secretin in treating autistic patients, together with the conflicting ...
Chan, SCY +5 more
core +1 more source
BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo. [PDF]
PLoS ONE, 2009 Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural ...
Guy Cheron +6 more
doaj +1 more source
The cerebellum could solve the motor error problem through error increase prediction [PDF]
, 2015 We present a cerebellar architecture with two main characteristics. The first one is that complex spikes respond to increases in sensory errors. The second one is that cerebellar modules associate particular contexts where errors have increased in the ...
O'Reilly, Randall C. +1 more
core +2 more sources