BK channels control cerebellar Purkinje and Golgi cell rhythmicity in vivo. [PDF]
PLoS ONE, 2009 Calcium signaling plays a central role in normal CNS functioning and dysfunction. As cerebellar Purkinje cells express the major regulatory elements of calcium control and represent the sole integrative output of the cerebellar cortex, changes in neural ...
Guy Cheron +6 more
doaj +1 more source
Purkinje Cells Pathology in Alzheimer’s Disease [PDF]
American Journal of Alzheimer's Disease & Other Dementias®, 2019 Alzheimer’s disease (AD) is one of the main causes of dementia in senium and presenium. It is clinically characterized by memory impairment, deterioration of intellectual faculties, and loss of professional skills. The cerebellum is a critical part in the distributed neural circuits participating not only in motor function but also in autonomic ...
Ioannis Mavroudis +5 more
openaire +2 more sources
The Purkinje–myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT
JCI Insight, 2022 Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmia syndrome caused by gene mutations that render RYR2 Ca release channels hyperactive, provoking spontaneous Ca release and delayed afterdepolarizations (DADs).
Daniel J. Blackwell +11 more
doaj +1 more source
Anti-Yo antibody uptake and interaction with its intracellular target antigen causes Purkinje cell death in rat cerebellar slice cultures: a possible mechanism for paraneoplastic cerebellar degeneration in humans with gynecological or breast cancers. [PDF]
PLoS ONE, 2015 Anti-Yo antibodies are immunoglobulin G (IgG) autoantibodies reactive with a 62 kDa Purkinje cell cytoplasmic protein. These antibodies are closely associated with paraneoplastic cerebellar degeneration in the setting of gynecological and breast ...
John E Greenlee +6 more
doaj +1 more source
Molecular Brain, 2009 Purkinje cells are a class of specialized neurons in the cerebellum, and are among the most metabolically active of all neurons, as they receive immense synaptic stimulation, and provide the only efferent output from the cerebellum.
Chakrabarti Lisa +4 more
doaj +1 more source
Effect of gestational diabetes on neuronal cells in rat cerebellum in early postnatal life [PDF]
, 2014 Previous study has shown the adverse effects of gestational diabetes on hippocampal neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on rat cerebellum in early postnatal life. In this experimental
Ghafari, S. +3 more
core +1 more source
Angewandte Chemie, EarlyView.We here developed a molecular tool for the optical control of UGGAA repeat RNA foci, a pathological hallmark of spinocerebellar ataxia type 31 (SCA31). The photoswitchable RNA‐binding ligand enabled reversible control of the RNA foci. UV irradiation induced the growth of the RNA foci, while subsequent visible light irradiation dissolved the structure ...
Yusuke Fujiwara +2 more
wiley +2 more sources
Calcium Imaging Reveals Coordinated Simple Spike Pauses in Populations of Cerebellar Purkinje Cells
Cell Reports, 2016 The brain’s control of movement is thought to involve coordinated activity between cerebellar Purkinje cells. The results reported here demonstrate that somatic Ca2+ imaging is a faithful reporter of Na+-dependent “simple spike” pauses and enables us to ...
Jorge E. Ramirez, Brandon M. Stell
doaj +1 more source
Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo
Cell Reports, 2020 Summary: The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood.
Charlotte Arlt, Michael Häusser
doaj +1 more source
Population-scale organization of cerebellar granule neuron signaling during a visuomotor behavior. [PDF]
, 2017 Granule cells at the input layer of the cerebellum comprise over half the neurons in the human brain and are thought to be critical for learning. However, little is known about granule neuron signaling at the population scale during behavior.
Aksay, Emre RF +5 more
core +2 more sources