Results 81 to 90 of about 126,114 (304)
Temperature-dependent consolidation of puromycin-susceptible memory in the goldfish [PDF]
, 1973 Memory of a shock-avoidance task in goldfish (Carassius auratus) maintained at 20[deg]C shows a temporal gradient of insusceptibility to post-trial injection of puromycin upon testing 7 days later.
Neale, Joseph H. +2 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Multiparameter analysis of apoptosis in puromycin-treated Saccharomyces cerevisiae.
, 2015 In Saccharomyces cerevisiae, a typical apoptotic phenotype is induced by some stress factors such as sugars, acetic acid, hydrogen peroxide, aspirin and age.
Falcieri, E +24 more
core +2 more sources
Studies on the Action of Tetracycline and Puromycin
Journal of Biological Chemistry, 1972 Abstract By means of a convenient method for separating phenylalanyl puromycin from diphenylalanyl puromycin, it was found that, upon reaction with puromycin, phenylalanyl transfer RNA bound to ribosomes at 5 to 6 mm Mg++ yields phenylalanyl puromycin exclusively while phenylalanyltRNA bound at 13 mm Mg++ yields diphenylalanyl puromycin as well as ...
S, Tanaka, K, Igarashi, A, Kaji
openaire +2 more sources
Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins
FEBS Open Bio, EarlyView.Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley +1 more source
Design, Synthese und Untersuchung photoaktivierbarer und -deaktivierbarer Puromycin Derivate
, 2021 Den photoaktivierbaren Schutzgruppen PPGs wurde als wichtige Werkzeuge, um z. B. biologische Prozesse zu untersuchen, in den letzten Jahren eine beachtliche Aufmerksamkeit zuteil.
Elamri, Isam
core
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
A new photocaged puromycin for an efficient labeling of newly translated porteins in living neurons
, 2018 Monitoring newly synthesized proteins is becoming increasingly important to charcterize proteome composition in regulatory networks. Puromycin is a peptidyl transfer inhibitor, widely used in cell biology for taggin newly synthesized proteins.
Josef Wachtveitl +13 more
core +1 more source
Synthetic and Systems Biotechnology, 2018 Natural product discovery is pivot for drug development, however, this endeavor is often challenged by the wide inactivation or silence of natural products biosynthetic pathways.
Xiaoli Yan +8 more
doaj +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source