ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang +5 more
wiley +1 more source
Advances in Metabolic Reprogramming and Immune Regulatory Mechanisms in Lung Cancer. [PDF]
Li X, Li X, Wu H, Li R.
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In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang +11 more
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MYC at the tumor-immune interface: mechanisms of immune escape and immunotherapy resistance. [PDF]
González-Larreategui Í +3 more
europepmc +1 more source
The spatial revolution in immuno-oncology: artificial intelligence decoding NK cell niches to predict therapeutic response. [PDF]
Gao YQ, Liu T, Yang Y.
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Stimulator of interferon genes (STING)-activating nanomedicines: Translating innate immune modulation into effective therapy for triple-negative breast cancer. [PDF]
Singhai H +6 more
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Emerging immune checkpoint targets and combination strategies in blood cancer immunotherapy. [PDF]
Al-Khreisat MJ +10 more
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Galectins at the crossroads of tumor immunity, metabolism, and metastasis: mechanisms, therapeutic resistance, and translational opportunities. [PDF]
Jin C, Wang W, Gao Y.
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Nanoplatform-Mediated Remodeling of the Immune Microenvironment in Renal Cell Carcinoma. [PDF]
Luo M +7 more
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