Results 31 to 40 of about 444 (217)

Game Tree Search-based Impulsive Orbital Pursuit–Evasion Game with Limited Actions

Space: Science & Technology
This paper focuses on the impulsive orbital pursuit–evasion game (OPEG) with limited action sets for the pursuer and evader. Initially, a mathematical model is developed by combining game theory and orbital dynamics, forming a finite-round impulsive OPEG
Wenyuan Xie, Liran Zhao, Zhaohui Dang
doaj   +1 more source

Pursuer’s Control Strategy for Orbital Pursuit-Evasion-Defense Game with Continuous Low Thrust Propulsion

Applied Sciences, 2019
This paper studies the orbital pursuit-evasion-defense problem with the continuous low thrust propulsion. A control strategy for the pursuer is proposed based on the fuzzy comprehensive evaluation and the differential game. First, the system is described
Junfeng Zhou, Lin Zhao, Jianhua Cheng, Shuo Wang, Yipeng Wang   +4 more
doaj   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Cooperative Hunting Strategy with a Superior Evader Based on Differential Game

Complexity, 2022
This paper considers a pursuit-evasion game with multiple pursuers and a superior evader. A novel cooperative pursuit strategy is proposed to capture a faster evader while maintaining a formation. First, the initial states including position distribution
Chunyan Wang, Weixiang Shi, Li Liang
doaj   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

Cooperative Pursuit-Evasion Games With a Flat Sphere Condition

IEEE Open Journal of Control Systems
In planar pursuit-evasion differential games considering a faster pursuer and a slower evader, the interception points resulting from equilibrium strategies lie on the Apollonius circle.
Dejan Milutinovic, Alexander Von Moll, Satyanarayana Gupta Manyam, David W. Casbeer, Isaac E. Weintraub, Meir Pachter   +5 more
doaj   +1 more source

On Some Pursuit and Evasion Differential Game Problems for an Infinite Number of First-Order Differential Equations

Journal of Applied Mathematics, 2012
We study pursuit and evasion differential game problems described by infinite number of first-order differential equations with function coefficients in Hilbert space l2.
Abbas Badakaya Ja'afaru, Gafurjan Ibragimov   +1 more
doaj   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Collaborative Control of UAV Swarms for Target Capture Based on Intelligent Control Theory

Mathematics
Real-time dynamic capture of a single moving target is one of the most crucial and representative tasks in UAV capture problems. This paper proposes a multi-UAV real-time dynamic capture strategy based on a differential game model to address this ...
Yuan Chi, Yijie Dong, Lei Zhang, Zhenyue Qiu, Xiaoyuan Zheng, Zequn Li   +5 more
doaj   +1 more source

Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis

Advanced Science, EarlyView.
Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason, Anindya Sen, Suhan Cho, Se Jong Lee, Keyata Thompson, Md Musavvir Mahmud, Poornima Dubey, Talia Guardia, Anthony Kim, Stuart Martin, Nathan Wright, Konstantinos Konstantopoulos, Aikaterini Kontrogianni‐Konstantopoulos   +12 more
wiley   +1 more source