Results 41 to 50 of about 1,951 (305)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Journal of Marine Science and EngineeringPursuit–evasion involves coupled, antagonistic decision-making and is prone to local-optimal behaviors when solved online under nonlinear dynamics and constraints.
Duan Gao, Mingzhi Chen, Yunhao Zhang
doaj +1 more source
Computer vision and pursuit–evasion game theoretical controls for ground robots
Advances in Mechanical Engineering, 2019 A hardware-in-loop control framework with robot dynamic models, pursuit–evasion game models, sensor and information solutions, and entity tracking algorithms is designed and developed to demonstrate discrete-time robotic pursuit–evasion games for real ...
Dan Shen +4 more
doaj +1 more source
Hierarchical Decompositions of Stochastic Pursuit-Evasion Games
2022 IEEE 61st Conference on Decision and Control (CDC), 2022 In this work we present a hierarchical framework for solving discrete stochastic pursuit-evasion games (PEGs) in large grid worlds. With a partition of the grid world into superstates (e.g., "rooms"), the proposed approach creates a two-resolution decision-making process, which consists of a set of local PEGs at the original state level and an ...
Yue Guan 0004 +3 more
openaire +2 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
A Simplified Pursuit-evasion Game with Reinforcement Learning
Periodica Polytechnica Electrical Engineering and Computer Science, 2021 In this paper we visit the problem of pursuit and evasion and specifically, the collision avoidance during the problem. Two distinct tasks are visited: the first is a scenario when the agents can communicate with each other online, meanwhile in the second scenario they have to only rely on the state information and the knowledge about other agents ...
Gabor Paczolay, István Á. Harmati
openaire +3 more sources
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Advanced Materials Technologies, EarlyView.Dense tactile streams from across the humanoid body converge on collide in a central wiring and data bottleneck. By relocating computation closer to and then into the skin itself, near‐ and in‐sensor architectures, together with neuromorphic computing, chart a path toward perception‐native electronic skin, in which the conversion of stimulus into ...
Mijin Kim +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen +3 more
wiley +2 more sources