Results 31 to 40 of about 12,669 (162)
PXR: A New Player in Atopic Dermatitis [PDF]
Journal of Investigative Dermatology, 2018 Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis.
Landon K, Oetjen +2 more
openaire +2 more sources
A SUMO-acetyl switch in PXR biology [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016 Post-translational modification (PTM) of nuclear receptor superfamily members regulates various aspects of their biology to include sub-cellular localization, the repertoire of protein-binding partners, as well as their stability and mode of degradation.
Wenqi Cui +6 more
openaire +2 more sources
Cells, 2022 The pregnane X receptor (PXR) regulates the metabolism of many xenobiotic and endobiotic substances. In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions.
Steffen Hirte +5 more
doaj +1 more source
Effect of enzalutamide on anticoagulant therapy with edoxaban in patients with prostate cancer
British Journal of Clinical Pharmacology, EarlyView.Aims Treatment with enzalutamide in prostate cancer is challenging due to its high potential for drug–drug interactions, particularly in the typically older population of patients with frequent comorbidities treated with multiple drugs, such as anticoagulants.
Catharina J. P. Op 't Hoog +8 more
wiley +1 more source
Pregnane X receptor in drug-induced liver injury: Friend or foe?
Liver Research, 2018 The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj +1 more source
Prioritising research on endocrine disruption in the marine environment: a global perspective
Biological Reviews, EarlyView.ABSTRACT A healthy ocean is a crucial life support system that regulates the global climate, is a source of oxygen and supports major economic activities. A vast and understudied biodiversity from micro‐ to macro‐organisms is integral to ocean health.
Patricia I. S. Pinto +23 more
wiley +1 more source
CAR and PXR: The xenobiotic-sensing receptors☆ [PDF]
Steroids, 2007 The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the steroid hormone receptors. In contrast,
Yoav E, Timsit, Masahiko, Negishi
openaire +2 more sources
Open ChemistryPesticide-induced liver toxicity remains a significant health concern, particularly with the widespread use of triazole fungicides such as propiconazole (PCZ), which is known to disrupt hepatic function through oxidative stress and nuclear receptor ...
Ounissi Ismahan +9 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source