Results 11 to 20 of about 13,268 (174)

PXR: a center of transcriptional regulation in cancer

Acta Pharmaceutica Sinica B, 2020
Pregnane X receptor (PXR, NR1I2) is a prototypical member of the nuclear receptor superfamily. PXR can be activated by both endobiotics and xenobiotics.
Jiong Yan, Yongdong Niu
exaly   +5 more sources

Hypomethylation of the PXR gene promoter drives its overexpression in cisplatin-resistant EOC [PDF]

Discover Oncology
Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy, with prognosis limited by extensive resistance to platinum-based therapy.
Juan Wang, Jing-Ya Zhou, Zhi-Cui Chen, Min Cheng, Yu-Chang Hu, Qing Han   +5 more
doaj   +2 more sources

Pregnane X receptor mitigates aristolochic acid–induced acute kidney injury via p53 ubiquitination [PDF]

Renal Failure
Aristolochic acid (AA), commonly used in Chinese herbal medicine to treat various diseases, can cause acute kidney injury (AKI). The pregnane X receptor (PXR), a nuclear receptor, is involved in drug metabolism, carcinogenesis, inflammation, apoptosis ...
Qianfang Liu, Fei Deng, Anqun Chen, Yu Liu   +3 more
doaj   +2 more sources

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites

Cells, 2022
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-activated transcription factor with high levels of expression in the liver. It not only plays a key role in drug metabolism and elimination, but also promotes tumor growth, drug resistance, and ...
Rajamanikkam Kamaraj, Martin Draštík, Jana Maixnerová   +2 more
exaly   +3 more sources

Resveratrol as an Inhibitor of Pregnane X Receptor (PXR): Another Lesson in PXR Antagonism

Journal of Pharmacological Sciences, 2014
.: The pregnane X receptor (PXR) plays a central role in the regulation of metabolism. Only few PXR antagonists have been described and the mechanism of PXR inhibition is mostly hypothetical or believed to be allosteric.
Tomas Smutny, Petr Pavek
doaj   +4 more sources

Pregnane X receptor protects against age-related bone loss in males via PI3K/Akt-mediated inhibition of apoptosis [PDF]

Cell Death Discovery
The pregnane X receptor (Pxr) regulates metabolism and inflammation, but its roles in bone homeostasis remain elusive. This study demonstrates that Pxr deficiency in bones induces osteoporotic phenotypes, with reduced trabecular bone mass, impaired ...
Shangzhi Li, Yu Xu, Wenpeng Xu, Dingxin Zhang, Xiangyu Lin, Peijie Hu, Haipeng Si   +6 more
doaj   +2 more sources

Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions

Frontiers in Pharmacology, 2016
Pregnane X receptor is a ligand-activated nuclear receptor that mainly controls inducible expression of xenobiotics handling genes including biotransformation enzymes and drug transporters.
Petr Pavek, Pavek Petr
exaly   +3 more sources

Nuclear receptors CAR and PXR as cardiometabolic regulators

Pharmacological Research
The constitutive androstane receptor (CAR) and pregnane X receptor (PXR) were initially described as xenobiotic sensors, but an increasing number of studies have linked their activity to other important physiological processes including glucose and lipid
Janne Hukkanen, Jenni Küblbeck, Jukka Hakkola, Jaana Rysä   +3 more
doaj   +4 more sources

Targeting pregnane X receptor with a potent agonist-based PROTAC to delay colon cancer relapse [PDF]

Oncogenesis
Tumor recurrence is frequently attributed to drug-tolerant cancer cells. We previously demonstrated that downregulation of the Pregnane X Receptor (PXR, NR1I2) reduces chemoresistance and prevents colorectal cancer recurrence in xenograft mouse models ...
Lucile Bansard, Guillaume Laconde, Vanessa Delfosse, Tiphaine Huet, Margaux Ayeul, Emilie Rigal, Quentin Donati, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Luc Brunel, Baptiste Legrand, Alain Chavanieu, Anthony R. Martin, Julie Pannequin, William Bourguet, Muriel Amblard, Jean Marc Pascussi   +16 more
doaj   +2 more sources

Bile acid dysmetabolism in inflammatory bowel diseases

Alʹmanah Kliničeskoj Mediciny, 2023
Aim: To summarize the state-of-the-art data on the molecular mechanisms of bile acid (BA) synthesis and absorption, their impaired absorption and receptor-dependent signaling, as well as on the effects of the gut microbiota on BA metabolism in ...
Daria A. Kuznetsova, Sergey V. Lapin, Irina V. Gubonina   +2 more
doaj   +1 more source