Results 31 to 40 of about 13,268 (174)
The FASEB Journal, 2021 Pregnane X receptor (PXR) is a nuclear receptor initially characterized as a xenobiotic‐sensing receptor that transcriptionally induces drug‐metabolizing enzymes and transporters to control the disposition of xenobiotics. Emerging data reveal PXR's broader roles in regulating glucose and lipid metabolism to control metabolic homeostasis.
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The Nuclear Receptor PXR in Chronic Liver Disease [PDF]
Cells, 2021 Pregnane X receptor (PXR), a nuclear receptor known for modulating the transcription of drug metabolizing enzymes and transporters (DMETs), such as cytochrome P450 3A4 and P-glycoprotein, is functionally involved in chronic liver diseases of different etiologies.
Sayaf K. +4 more
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Frontiers in Endocrinology, 2022 The pregnane X receptor (PXR) is a master xenobiotic-sensing receptor in response to toxic byproducts, as well as a key regulator in intermediary lipid metabolism.
Hongyan Li +8 more
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Deficiency of PXR decreases atherosclerosis in apoE-deficient mice
Journal of Lipid Research, 2011 The pregnane X receptor (PXR, also known as SXR) is a nuclear hormone receptor activated by xenobiotics as well as diverse sterols and their metabolites.
Yipeng Sui +3 more
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PXR is a target of (-)-epicatechin in skeletal muscle [PDF]
Heliyon, 2020 (-)-Epicatechin (EC) is a flavanol that has shown numerous biological effects such as: decrease risk of cardiovascular dysfunction, metabolism regulation, skeletal muscle (SkM) performance improvement and SkM cells differentiation induction, among others. The described EC acceptor/receptor molecules do not explain the EC's effect on SkM. We hypothesize
Miguel Ortiz-Flores +7 more
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Journal of Lipid Research, 2020 The pregnane X receptor (PXR) is a nuclear receptor that can be activated by numerous drugs and xenobiotic chemicals. PXR thereby functions as a xenobiotic sensor to coordinately regulate host responses to xenobiotics by transcriptionally regulating many
Yipeng Sui +7 more
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PXR: A New Player in Atopic Dermatitis [PDF]
Journal of Investigative Dermatology, 2018 Epidemiological evidence suggests that environmental pollutants contribute to atopic dermatitis, but mechanistic details are currently lacking. Elentner et al. show that PXR, a key transcription factor involved in pollutant metabolism, drives features of subclinical atopic dermatitis.
Landon K, Oetjen +2 more
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The Role of PXR Genotype and Transporter Expression in the Placental Transport of Lopinavir in Mice
Pharmaceutics, 2017 Lopinavir (LPV), an antiretroviral protease inhibitor frequently prescribed in HIV-positive pregnancies, is a substrate of Abcb1 and Abcc2. As differences in placental expression of these transporters were seen in Pregnane X Receptor (PXR) −/− mice, we ...
Sarabjit S. Gahir +1 more
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Diagnostics, 2021 Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance.
Stamatios Theocharis +11 more
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Journal of Lipid Research, 2009 The nuclear hormone receptor pregnane X receptor (PXR; also called SXR) functions as a xenobiotic sensor to coordinately regulate xenobiotic metabolism via transcriptional regulation of xenobiotic-detoxifying enzymes and transporters.
Changcheng Zhou +3 more
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