Results 41 to 50 of about 13,268 (174)
Small-molecule modulators of PXR and CAR [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016 Two nuclear receptors, the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR), participate in the xenobiotic detoxification system by regulating the expression of drug-metabolizing enzymes and transporters in order to degrade and excrete foreign chemicals or endogenous metabolites.
Sergio C, Chai +3 more
openaire +2 more sources
Novel complex of HAT protein TIP60 and nuclear receptor PXR promotes cell migration and adhesion
Scientific Reports, 2017 PXR is a member of nuclear receptor superfamily and a well-characterized mediator of xenobiotic metabolism. The classical mode of PXR activation involves its binding to appropriate ligand and subsequent heterodimerization with its partner RXR.
Karishma Bakshi +5 more
doaj +1 more source
PXR and 4β-Hydroxycholesterol Axis and the Components of Metabolic Syndrome
Cells, 2020 Pregnane X receptor (PXR) activation has been found to regulate glucose and lipid metabolism and affect obesity in response to high-fat diets. PXR also modulates vascular tone.
Janne Hukkanen, Jukka Hakkola
doaj +1 more source
A SUMO-acetyl switch in PXR biology [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2016 Post-translational modification (PTM) of nuclear receptor superfamily members regulates various aspects of their biology to include sub-cellular localization, the repertoire of protein-binding partners, as well as their stability and mode of degradation.
Wenqi Cui +6 more
openaire +2 more sources
Animal Research and One Health, EarlyView.Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang +6 more
wiley +1 more source
Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis
Angewandte Chemie, Volume 138, Issue 25, 15 June 2026.Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley +2 more sources
Open ChemistryPesticide-induced liver toxicity remains a significant health concern, particularly with the widespread use of triazole fungicides such as propiconazole (PCZ), which is known to disrupt hepatic function through oxidative stress and nuclear receptor ...
Ounissi Ismahan +9 more
doaj +1 more source
Pregnane X receptor in drug-induced liver injury: Friend or foe?
Liver Research, 2018 The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cell ...
Amina I. Shehu, Xiaochao Ma
doaj +1 more source
Cells, 2022 The pregnane X receptor (PXR) regulates the metabolism of many xenobiotic and endobiotic substances. In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions.
Steffen Hirte +5 more
doaj +1 more source