Results 101 to 110 of about 159,479 (261)

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Identifying the signature of NAD+ metabolism-related genes for immunotherapy of gastric cancer

Heliyon
NAD (Nicotinamide Adenine Dinucleotide) -related metabolic reprogramming in tumor cells involves multiple vital cellular processes. However, the role of NAD metabolism in immunity and the prognosis of gastric cancer (GC) remains not elucidated.
Huijuan Wen, Yang Mi, Fazhan Li, Xia Xue, Xiangdong Sun, Pengyuan Zheng, Simeng Liu   +6 more
doaj   +1 more source

Tofacitinib Regulates β‐Catenin Nuclear Translocation to Inhibit FLS Migration and Alleviate Clinical Symptoms of RA

iNew Medicine, EarlyView.
ABSTRACT Objective Tofacitinib is a Janus kinase (JAK) inhibitor approved for the treatment of moderate‐to‐severe rheumatoid arthritis (RA). However, its synovium‐related molecular mechanisms, particularly its regulatory effect on fibroblast‐like synoviocyte (FLS) migration, remain incompletely understood.
Shuqi Fang, Tianjing Zhang, Ling Hu, Ruijin Liu, Leyi Jia, Menglin Bai, Jiale Dong, Yuchen Zhao, Han Wang, Lei Zhang, Tao Li, Youcai Deng, Xianzheng Zhang, Lingling Zhang   +13 more
wiley   +1 more source

Profiling gut microbiota of colorectal cancer in Indonesia: a focus on beneficial taxa depletion

Gut Pathogens
Introduction Regional differences in the gut microbiota and CRC incidence and mortality rates are well-documented. However, studies on the microbiota associated with CRC in Indonesia remain scarce.
Yudith Annisa Ayu Rezkitha, Amal Arifi Hidayat, Irene Normalina, Ricky Indra Alfaray, Priyo Budi Purwono, Maria Inge Lusida, Brahmana Askandar Tjokroprawiro, Isna Mahmudah, Hasan Maulahela, Yoshio Yamaoka, Muhammad Miftahussurur   +10 more
doaj   +1 more source

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Microbial Cell, 2017
H. pylori is a Gram-negative extracellular bacterium, first discovered by the Australian physicians Barry Marshall and Robin Warren in 1982, that colonises the human stomach mucosa.
Hong Li, Tiandi Yang, Tingting Liao, Aleksandra W. Debowski, Hans-Olof Nilsson, Stuart M. Haslam, Anne Dell, Keith A. Stubbs, Barry J. Marshall, Mohammed Benghezal   +9 more
doaj   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Helicobacter pylori FlhB function: the F1hB C-terminal homologue HP1575 acts as a "Spare part" to permit flagellar export when the HP0770 FlhB(CC) domain is deleted [PDF]

, 2006
In Helicobacterpylori 26695, a gene annotated HP1575 encodes a putative protein of unknown function which shows significant similarity to part of the C-terminal domain of the flagellar export protein FlhB.
K. J. Evans, N. Doherty, P. M. Sharp, R. E. Sockett, K. R. Hardie, Hardie, Kim R., Winzer, Klaus, K. Winzer, Sharp, Paul M., M. E. Wand, Wand, Matthew E., Evans, Katy J., Doherty, Neil, Sockett, R. Elizabeth   +13 more
core   +1 more source

Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple   +3 more
wiley   +1 more source

Gut microbiota and its therapeutic implications in tumor microenvironment interactions

Frontiers in Microbiology
The development of cancer is not just the growth and proliferation of a single transformed cell, but its tumor microenvironment (TME) also coevolves with it, which is primarily involved in tumor initiation, development, metastasis, and therapeutic ...
Pengya Feng, Pengya Feng, Pengya Feng, Xia Xue, Xia Xue, Ihtisham Bukhari, Ihtisham Bukhari, Chunjing Qiu, Chunjing Qiu, Yingying Li, Yingying Li, Pengyuan Zheng, Pengyuan Zheng, Yang Mi, Yang Mi   +14 more
doaj   +1 more source

Dietary management and feeding considerations of pediatric aerodigestive and upper gastrointestinal motility disorders: A position paper by the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) Neurogastroenterology and Motility Committee

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objective Pediatric aerodigestive and upper gastrointestinal (UGI) motility disorders are common and may be associated with compromised nutritional status and decreased quality of life. Traditional dietary recommendations for aerodigestive and UGI motility disorders have been rudimentary and largely based upon experience and common sense ...
Khalil El‐Chammas, Kirsten B. Jones, Joan Arvedson, Mary Boruta, Erick Toro‐Monjaraz, Anita Sicolo, Anil Darbari, Rachel Rosen, Julie Khlevner   +8 more
wiley   +1 more source