Results 1 to 10 of about 4,993 (136)

Rapid development of cefiderocol resistance in a carbapenem-resistant Pseudomonas aeruginosa isolate associated with mutations in the pyoverdine biosynthesis pathway

Journal of Global Antimicrobial Resistance, 2023
: Here we report the in vivo development of cefiderocol resistance within 11 days after therapy initiation in a critically ill patient with bloodstream infection, infection of peri-anal fistula, and pneumonia caused by a VIM-2 harbouring, carbapenem ...
Luise Brakert, Laura Berneking, Anna Both, Benjamin Berinson, Jiabin Huang, Martin Aepfelbacher, Christine Wolschke, Dominic Wichmann, Holger Rohde   +8 more
doaj   +2 more sources

Biosynthesis of a clickable pyoverdine via in vivo enzyme engineering of an adenylation domain

Microbial Cell Factories
The engineering of non ribosomal peptide synthetases (NRPS) for new substrate specificity is a potent strategy to incorporate non-canonical amino acids into peptide sequences, thereby creating peptide diversity and broadening applications.
Hélène Puja, Laurent Bianchetti, Johan Revol-Tissot, Nicolas Simon, Anastasiia Shatalova, Julian Nommé, Sarah Fritsch, Roland H. Stote, Gaëtan L. A. Mislin, Noëlle Potier, Annick Dejaegere, Coraline Rigouin   +11 more
doaj   +2 more sources

Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients

Frontiers in Microbiology, 2019
The development of therapies that modulate or prevent pathogen virulence may be a key strategy for circumventing antimicrobial resistance. Toward that end, we examined the production of pyoverdine, a key virulence determinant, in ∼70 Pseudomonas ...
Donghoon Kang, Alexey V. Revtovich, Qingquan Chen, Kush N. Shah, Carolyn L. Cannon, Natalia V. Kirienko   +5 more
doaj   +2 more sources

An In Vitro Cell Culture Model for Pyoverdine-Mediated Virulence

Pathogens, 2020
Pseudomonas aeruginosa is a multidrug-resistant, opportunistic pathogen that utilizes a wide-range of virulence factors to cause acute, life-threatening infections in immunocompromised patients, especially those in intensive care units.
Donghoon Kang, Natalia V. Kirienko
doaj   +2 more sources

A Holistic Approach from Systems Biology Reveals the Direct Influence of the Quorum-Sensing Phenomenon on Pseudomonas aeruginosa Metabolism to Pyoverdine Biosynthesis

Metabolites, 2023
Computational modeling and simulation of biological systems have become valuable tools for understanding and predicting cellular performance and phenotype generation.
Diana Carolina Clavijo-Buriticá, Catalina Arévalo-Ferro, Andrés Fernando González Barrios   +2 more
doaj   +2 more sources

Overexpression of the MexXY Multidrug Efflux System Correlates with Deficient Pyoverdine Production in Pseudomonas aeruginosa

Antibiotics, 2021
Multidrug-resistant Pseudomonas aeruginosa poses a serious problem due to hospital- and healthcare-associated infections. A major drug resistance mechanism of P.
Kei Ikarashi, Ryo Kutsuna, Junko Tomida, Yoshiaki Kawamura, Yuji Morita   +4 more
doaj   +2 more sources

Pyoverdine, a siderophore from Pseudomonas aeruginosa, translocates into C. elegans, removes iron, and activates a distinct host response

Virulence, 2018
Pseudomonas aeruginosa, a re-emerging, opportunistic human pathogen, encodes a variety of virulence determinants. Pyoverdine, a siderophore produced by this bacterium, is essential for pathogenesis in mammalian infections.
Donghoon Kang, Daniel R. Kirienko, Phillip Webster, Alfred L. Fisher, Natalia V. Kirienko   +4 more
doaj   +2 more sources

Identification and validation of a novel anti-virulent that binds to pyoverdine and inhibits its function

Virulence, 2020
Pseudomonas aeruginosa: causes serious infections in patients with compromised immune systems and exhibits resistance to multiple antibiotics. The rising threat of antimicrobial resistance means that new methods are necessary for treating microbial ...
Xu Wang, Quinn Kleerekoper, Alexey V. Revtovich, Donghoon Kang, Natalia V. Kirienko   +4 more
doaj   +2 more sources

Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis

Frontiers in Microbiology, 2019
Pseudomonas aeruginosa is a clinically important pathogen that causes a variety of infections, including urinary, respiratory, and other soft-tissue infections, particularly in hospitalized patients with immune defects, cystic fibrosis, or significant ...
Daniel R. Kirienko, Donghoon Kang, Natalia V. Kirienko   +2 more
doaj   +2 more sources

Pyoverdine-antibiotic combination treatment: its efficacy and effects on resistance evolution in Escherichia coli. [PDF]

Microlife
Antibiotic resistance is a growing concern for global health, demanding innovative and effective strategies to combat pathogenic bacteria. Pyoverdines, iron-chelating siderophores produced by environmental Pseudomonas spp., present a novel promising ...
Vollenweider V, Roncoroni F, Kümmerli R.   +2 more
europepmc   +2 more sources