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High-Throughput Genetic Screen Reveals that Early Attachment and Biofilm Formation Are Necessary for Full Pyoverdine Production by Pseudomonas aeruginosa [PDF]
Pseudomonas aeruginosa is a re-emerging, multidrug-resistant, opportunistic pathogen that threatens the lives of immunocompromised patients, patients with cystic fibrosis, and those in critical care units.
Donghoon Kang, Natalia V. Kirienko
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Enzymology of the periplasmic pyoverdine maturation
Iron is of prominent importance for most living organisms, involved in many central processes, such as respiration or photosynthesis. To circumvent iron limitation, many organisms have developed strategies to keep ferric iron soluble, for instance by ...
Ringel, Michael Thomas
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The biosynthesis of pyoverdines [PDF]
Pyoverdines are fluorescent siderophores of pseudomonads that play important roles for growth under iron-limiting conditions. The production of pyoverdines by fluorescent pseudomonads permits their colonization of hosts ranging from humans to plants.
Michael T. Ringel, Thomas Brüser
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Multidrug-resistant Pseudomonas aeruginosa poses a serious problem due to hospital- and healthcare-associated infections. A major drug resistance mechanism of P.
Kei Ikarashi +4 more
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Pyoverdine aus Pseudomonas putida / Pyoverdins from Pseudomonas putida
The structures of two pyoverdins (Pp 1 and Pp 2) and one dihydropyoverdin (dihydro-Pp 2) from a strain of Pseudomonas putida have been elucidated by spectroscopic methods and degradation studies. The pyoverdins Pp 1 and Pp2 consist of a chromophore which was identified as (1 S)-5-amino-2,3-dihydro-8,9-dihydroxy-1 H-pyrimido[1,2-a]quinoline-1-carboxylic
I. Gwose, K. Taraz
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: Here we report the in vivo development of cefiderocol resistance within 11 days after therapy initiation in a critically ill patient with bloodstream infection, infection of peri-anal fistula, and pneumonia caused by a VIM-2 harbouring, carbapenem ...
Luise Brakert +8 more
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Total Synthesis of Pyoverdin D
Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including (δ)N-formyl-(δ)N-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total
Roi Mashiach, Michael M. Meijler
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Siderophore activity of pyoverdin for Pseudomonas aeruginosa [PDF]
Pseudomonas aeruginosa produces an extracellular compound with yellowish green fluorescence, called pyoverdin, which functions as a siderophore. The production of pyoverdin, formerly called fluorescein, is concomitant with the production of another siderophore, pyochelin. Pyoverdin is produced by P.
C D, Cox, P, Adams
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Pyoverdine-Dependent Virulence of Pseudomonas aeruginosa Isolates From Cystic Fibrosis Patients
The development of therapies that modulate or prevent pathogen virulence may be a key strategy for circumventing antimicrobial resistance. Toward that end, we examined the production of pyoverdine, a key virulence determinant, in ∼70 Pseudomonas ...
Donghoon Kang +5 more
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The RND efflux system ParXY affects siderophore secretion in Pseudomonas putida KT2440
Tripartite efflux systems transport antimicrobial agents, toxic metabolites, and siderophores from Gram-negative cells into the environment. For example, the main siderophore pyoverdine of the soil bacterium Pseudomonas putida KT2440 is secreted into the
Nicola Victoria Stein +6 more
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