Results 61 to 70 of about 7,109 (211)

Synthesis and Biological Profile of Substituted Pyrrolidinyl Carboxamides for Acyl‐ACP Thioesterase Inhibition

European Journal of Organic Chemistry, EarlyView.
The work outlined herein covers a series of novel herbicidal lead structures that possess a pyrrolidinyl pyrazole carboxamide scaffold as a key structural feature, carrying further substituted benzyl side chains. Based on scaffold hopping approaches from known fungicidal and herbicidal compounds and utilizing an optimized synthetic approach, a broader ...
Elisabeth Asmus, Martin Annau, Neanne Alnafta, David M. Barber, Guido Bojack, Birgit Bollenbach‐Wahl, Ralf Braun, Ronald W. Brown, Luke R. Churchman, Christine Dörnbrack, Andrew Earl, Tyler Fahrenhorst‐Jones, Jörg Freigang, Claudia Hartfiel, Ines Heinemann, Arnim Köhn, Bernd Laber, Michael C. McLeod, Catherine S. Meister, Gudrun Lange, Luka Posa, Shaun Rees, Dirk Schmutzler, Anna M. Reingruber, Jens Frackenpohl   +24 more
wiley   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, EarlyView.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Dichlorido{N,N,N′-trimethyl-N′-(1H-pyrazol-1-yl-κN2)methyl]ethane-1,2-diamine-κ2N,N′}copper(II) methanol monosolvate

IUCrData, 2019
In the title compound, [CuCl2(C9H18N4)]·CH3OH, the central CuII ion is coordinated by three N atoms from the pyrazole derivative ligand and two chloride co-ligands. The coordination geometry around the CuII ion is distorted trigonal–bipyramidal.
Ravindra Singh, Akram Ali, Md. Serajul Haque Faizi, Roona Singh, Turganbay S. Iskenderov, Necmi Dege   +5 more
doaj   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Future Journal of Pharmaceutical Sciences
Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer.
Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla   +3 more
doaj   +1 more source

Crystal structure of 6-amino-4-(3-bromo-4-methoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile dimethyl sulfoxide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the pyrazole molecule of the title solvate, C15H13BrN4O2·C2H6OS, the dihedral angle between the benzene ring and the mean plane of the dihydropyrano[2,3-c]pyrazole ring system [r.m.s deviation = 0.031 (2) Å] is 86.71 (14)°.
Sammer Yousuf, Huma Bano, Munira Taj Muhammad, Khalid Mohammed Khan   +3 more
doaj   +1 more source

Synthetic polymer nanocarrier enhances dsRNA stability but not RNAi efficacy in Brassicogethes aeneus

Pest Management Science, EarlyView.
Experimental setup for dsRNA feeding in Brassicogethes aeneus to evaluate the effect of a synthetic polymer nanocarrier on RNAi efficiency. The experiment assessed whether the nanocarrier enhances RNAi after oral dsRNA delivery. (a) Stability of dsRNA–nanocarrier complexes was tested in simulated gut conditions. (b) Gene expression of αCOP and dre4 was
Triin Kallavus, Liina Soonvald, Iris Callewaert, Ana Isabel Silva, Ericmar Ávila Dos Santos, Silva Vilumets, Riina Kaasik, Sven Vereecken, Lenny Van Daele, Peter Dubruel, Jonathan Willow, Clauvis Nji Tizi Taning, Kristof De Schutter, Eve Veromann   +13 more
wiley   +1 more source

The synthesis and evaluation of 3-benzoylbenzofurans and their pyrazole derivatives against HIV-1 infections and cancer

International Journal of Infectious Diseases
Introduction: The human immunodeficiency virus-1 (HIV-1) remains one of the leading global epidemics in the world. The HIV/AIDS epidemic is particularly dominant in Eastern and Southern Africa, as is evident by the 670 000 annual new infections in this ...
Ms Sinothile Khuzwayo, Dr Mamoalosi A Selepe, Prof. Debra Mayer, Dr Ntombenhle Hlengiwe Gama   +3 more
doaj   +1 more source

The pyrazole derivative of usnic acid inhibits the proliferation of pancreatic cancer cells in vitro and in vivo. [PDF]

Cancer Cell Int, 2023
Gimła M, Pyrczak-Felczykowska A, Malinowska M, Hać A, Narajczyk M, Bylińska I, Reekie TA, Herman-Antosiewicz A.   +7 more
europepmc   +1 more source

Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management

Pest Management Science, EarlyView.
Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela, Teófilo P Langa, José VCR Dantas, Marcos de Oliveira, Herbert AA Siqueira   +4 more
wiley   +1 more source