Results 181 to 190 of about 27,892 (233)

Design, Synthesis, and Antibacterial Evaluation of Pyrazole Pyrimidine Hybrids: Integrative In Vitro and In Silico Studies

ChemistrySelect, Volume 10, Issue 17, May 5, 2025.
This study synthesizes novel pyrimidine–pyrazole hybrids and evaluates their antimicrobial activity against bacterial pathogens by targeting penicillin‐binding protein 3 (PBP3). Several compounds show significant activity against E. faecium. Docking studies reveal strong binding with HMG‐CoA synthase, while in silico pharmacokinetic predictions ...
Suresh Choppadandi, Divya Vemula, Nagaraju Kerru, Vasundhra Bhandari, Chilukoti Srilakshmi   +4 more
wiley   +1 more source

Transforming an azaarene into the spine of fusedbicyclics via cycloaddition-induced scaffold hopping of 5-Hydroxypyrazoles. [PDF]

Nat Commun
Zhou Y, Lei SG, Abudureheman B, Wang LS, Yu ZC, Xiang JC, Wu AX.   +6 more
europepmc   +1 more source

Synthesis of 3-Substituted Pyrrolo[3, 4-c]pyrazole-4, 6(1H, 5H)-dione Derivatives by Addition of Aryldiazomethane on N-Phenylmaleimide

, 1977
Kiichi Arakawa, Tadashi Miyasaka, Norimitsu Hamamichi   +2 more
openalex   +2 more sources

Estrogens produced within the central amygdala inhibit varicella zoster‐induced orofacial pain

Journal of Neuroendocrinology, Volume 37, Issue 5, May 2025.
Abstract Varicella zoster virus (VZV) causes chicken pox, and reactivation of this virus later in life causes shingles. Previous work demonstrated that estrogens could reduce VZV‐induced orofacial pain and affect gene expression in the central amygdala.
Phillip Kramer, Lauren Nguyen, Paul R. Kinchington   +2 more
wiley   +1 more source

Editorial: Five-membered ring heterocyclic compounds as anticancer drug candidates. [PDF]

Front Chem
Mermer A, Orhan İE, Ye G, Kumar NA, Danac R.   +4 more
europepmc   +1 more source

Synthesis of Selectively 13C/2H/15N‐ Labeled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy

Chemistry – A European Journal, Volume 31, Issue 24, April 25, 2025.
We offer a new labeling approach to introduce isolated 15N−13C−1H spin systems to the side chains of arginine residues. The labeling scheme delivers high‐resolution NMR spectra to study large protein complexes. The interaction between ubiquitin and the third Src homology 3 domain of yeast protein Sla1 (Sla1 SH3‐3) has been analyzed, highlighting the ...
Darja I. Rohden, Giorgia Toscano, Paul Schanda, Roman J. Lichtenecker   +3 more
wiley   +1 more source

Switching Sides: Regiochemistry and Functionalization Dictate the Photoswitching Properties of Imines. [PDF]

Angew Chem Int Ed Engl
Wu J, Kreimendahl L, Greenfield JL.
europepmc   +1 more source

A reagent to access methyl sulfones. [PDF]

Nat Commun
Poplavskyi Y, Ripenko V, Bova S, Biitseva A, Dmitriv YV, Tolmachev AA, Sadkova IV, Pishel I, Grygorov O, Phan VQH, Dias HVR, Mykhailiuk PK.   +11 more
europepmc   +1 more source

Bioactive Fused Pyrazoles Inspired by the Adaptability of 5-Aminopyrazole Derivatives: Recent Review. [PDF]

Molecules
Odeh DM, Odeh MM, Hafez TS, Hassan AS.
europepmc   +1 more source

Photocatalytic‐Mediated C−H Activation of Toluene Using Copper(I)‐Complexes with Macrocyclic Ligands

European Journal of Inorganic Chemistry, Volume 28, Issue 12, April 17, 2025.
The selective oxidation of toluene to benzaldehyde was successfully carried out via a photocatalytically mediated reaction using copper complexes with macrocyclic ligands and molecular dioxygen. The process demonstrated a high turnover number for the conversion of toluene to benzaldehyde, with no detectable side products.
Christian Noß, Richard Göttlich, Siegfried Schindler   +2 more
wiley   +1 more source