Results 221 to 230 of about 10,045 (252)

[Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine].

Die Pharmazie, 1990
Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3 ...
H H, Borchert, S, Pfeifer, B, Helbig, P, Franke, G, Heinisch   +4 more
openaire   +1 more source

Pyridazines. XLVI. Ring Opening of Some Azolo and Azino Pyridazines

Synthetic Communications, 1971
Abstract A facile cleavage of the five-membered ring of certain quaternary s-triazolo (4, 3-b)pyridazines under basic conditions was recorded recently2. We report now several interesting cases of the six-membered ring opening in some related systems under similar conditions.
A. Pollak, B. Stanovnik, M. Tišler
openaire   +1 more source

Pyridazine-derived γ-secretase modulators

Bioorganic & Medicinal Chemistry Letters, 2011
SAR of a novel series of pyridazine-derived γ-secretase modulators is described. Compound 25 was found to be a potent modulator in vitro, which on further profiling, was found to decrease Aβ42 and Aβ40, and maintain the levels of total Aβ. Furthermore, 25 demonstrated excellent pharmacokinetic parameters as well as good CNS penetration in the rat.
Zehong, Wan, Adrian, Hall, Yun, Jin, Jia-Ning, Xiang, Eric, Yang, Andrew, Eatherton, Beverley, Smith, Guang, Yang, Haihua, Yu, Ju, Wang, Liang, Ye, Lit-Fui, Lau, Ting, Yang, William, Mitchell, Wei, Cai, Xiaomin, Zhang, Yingxia, Sang, Yonghui, Wang, Zhaolong, Tong, Ziqiang, Cheng, Ishrut, Hussain, John D, Elliott, Yasuji, Matsuoka   +22 more
openaire   +2 more sources

Pyridazines

2021
Jie Jack Li, Minmin Yang
openaire   +1 more source

Pyridazines. XXXVII. Pyrimido[1,2-b]pyridazines

The Journal of Organic Chemistry, 1971
Miha Tisler, Alfred Pollak, Branko Stanovnik   +2 more
openaire   +1 more source

Chapter 13 Pyridazines

2007
Publisher Summary The pyridazine nucleus is a π-deficient aromatic heterocycle. Each nitrogen atom of the 1,2-diazine activates its α- and γ-position for nucleophilic attack. Consequently, all ring carbon atoms are deactivated for electrophilic substitution.
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Pyridazines XXIV

Tetrahedron, 1985
Gottfried Heinisch, Gerhard Lötsch
openaire   +1 more source

Pyridazines

1968
M. Tišler, B. Stanovnik
openaire   +1 more source

Pyridazine Rearrangements

Tetrahedron Letters, 1973
R.D. Chambers, M. Clark, J.R. Maslakiewicz, W.K.R. Musgrave   +3 more
openaire   +1 more source

Pyridazines I

Journal of Pharmaceutical Sciences, 1963
Winnifred M. Osner, Raymond N. Castle, Duane L. Aldous   +2 more
openaire   +1 more source