Results 31 to 40 of about 10,186 (207)

Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. [PDF]

Angew Chem Int Ed Engl
The intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
Knaack JIH, List E, Stalling D, Sterrenberg VT, Meier C, Wagenknecht HA, Bosse JB.   +6 more
europepmc   +2 more sources

Pyridazines. XI. Pyrido[2, 3-d]pyridazines. II

Chemical and Pharmaceutical Bulletin, 1966
8-Oxo-7, 8-dihydropyrido[2, 3-d]pyridazine-5-carboxylic acid, 7-phenyl-8-oxo-7, 8-dihydropyrido[2, 3-d]pyridazine-5-carboxylic acid, and their esters, amides and hydrazides were prepared. Alkaline hydrolysis of 7-phenyl-8-oxo-7, 8-dihydroprido[2, 3-d]pyridazine-5-carboxylates gave phenylhydrazone of 3-formylpicolinic acid and good yields of 3-(2 ...
Ikutoshi Matsuura, Fumio Yoneda, Yoshihiro Nitta   +2 more
openaire   +2 more sources

Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines

Molecules, 2009
Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively.
Mohamed Hilmy Elnagdi, Heinz Kolshorn, Herbert Meier, Saleh M. Al-Mousawi, Moustafa Sherief Moustafa   +4 more
doaj   +1 more source

Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold

South Asian Research Journal of Pharmaceutical Sciences, 2019
Pyridazine and pyridazinone derivatives compounds are biologically important compounds. Pyridazinone has carbonyl group on third carbon on pyridazine ring.
A. ., Md. Tauquir Alam, M. Asif
semanticscholar   +1 more source

Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

Beilstein Journal of Organic Chemistry, 2017
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, Ali Hachem   +5 more
doaj   +1 more source

Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines

Chemistry Central Journal, 2016
BackgroundIsoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry.
Y. H. Zaki, A. R. Sayed, S. Elroby
semanticscholar   +1 more source

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Hydrogen Bonding is Key Factor in Reversible NH3 Uptake Causing Vapochromic and Magnetochemical Switching in Ni(II) Paddlewheel Complexes

ChemistryEurope, EarlyView.
Nickel complexes showing reversible vapochromic and spin crossover behaviors upon coordination and release of NH3 were synthesized. They bear bidentate pyridazine ligands, which allows for formation of hydrogen bonds between NH3 and the ligand in the second coordination sphere.
Sebastian Rücker, Jörg A. Schachner, Sergey M. Borisov, Ferdinand Belaj, Silvia Carlotto, Lidia Armelao, Antoine Dupé, Nadia C. Mösch‐Zanetti   +7 more
wiley   +1 more source

4,7-Dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide

Molbank, 2018
Dihalogenated derivatives of [1,2,5]chalcogenadiazolo[3,4-d]pyridazines are of interest as precursors for both photovoltaic materials and biologically active compounds.
Timofey Chmovzh, Ekaterina Knyazeva, Vadim Popov, Oleg Rakitin   +3 more
doaj   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source