Results 31 to 40 of about 10,045 (252)
Tandem mass spectrometric study of annelation isomers of the novel thieno[3',2':4,5]pyrido[2,3-d]pyridazine ring system [PDF]
, 2014 In the present communication, we describe tandem combinations of Suzuki - condensation ring closure reactions to obtain a novel thieno[3 -,2 -:4,5]pyrido[2,3-d]pyridazine ring system. These compounds were studied by tandem mass spectrometry in detail and
Krajsovszky, Gábor +2 more
core +1 more source
Molecules, 2021 A series of novel 3-phenoxy-4-(3-trifluoromethylphenyl)pyridazines 2–5 were designed, based on the structure of our previous lead compound 1 through the in silico structure-guided optimization approach. The results showed that some of these new compounds
Lijun Yang +7 more
doaj +1 more source
High Throughput Screening of a GlaxoSmithKline Protein Kinase Inhibitor Set Identifies an Inhibitor of Human Cytomegalovirus Replication that Prevents CREB and Histone H3 Post-Translational Modification. [PDF]
, 2017 To identify new compounds with anti-human cytomegalovirus (HCMV) activity and new anti-HCMV targets, we developed a high throughput strategy to screen a GlaxoSmithKline (GSK) Published Kinase Inhibitor Set (PKIS).
Ho, CMK +5 more
core +3 more sources
The first metal complexes of 3,3'-bi-1,2,4-oxadiazole: A curiously ignored ligand [PDF]
, 2006 The crystal structure of 3,3'-bi-1,2,4-oxadiazole (1) reveals a planar centrosymmetric structure for this molecule in the solid state. It forms a mononuclear complex (3) with palladium(II) chloride, which is shown by X-ray crystallography to contain the ...
Richardson, C., Steel, P.J.
core +4 more sources
Reactivity and Synthetic Applications of 4,5-Dicyanopyridazine: An Overview
Molecules, 2010 Despite the poor reputation of electron-deficient pyridazines in intermolecular Hetero Diels-Alder (HDA) reactions, 4,5-dicyanopyridazine (DCP) showed a surprising reactivity as a heterocyclic azadiene in inverse electron-demand HDA processes with ...
Donatella Giomi +2 more
doaj +1 more source
Molecules, 2022 In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities.
Otmane Bourzikat +9 more
doaj +1 more source
Boron Trifluoride-Mediated Cycloaddition of 3-Bromotetrazine and Silyl Enol Ethers: Synthesis of 3-Bromo-pyridazines [PDF]
, 2021 Pyridazines are important scaffolds for medicinal chemistry or crop protection agents, yet the selective preparation of 3-bromo-pyridazines with high regiocontrol remains difficult.
Gademann, Karl +4 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2017 The novel cascade two-stage reaction between itaconimides and 1,2-diamino-4-phenylimidazole proceeds regio- and chemoselectively to form tetrahydroimidazo[1,5-b]pyridazines and includes nucleophilic C-addition by the activated C=C double bond and ...
Dmitry Yu. Vandyshev +5 more
doaj +1 more source
Pyridazines. XI. Pyrido[2, 3-d]pyridazines. II
Chemical and Pharmaceutical Bulletin, 1966 8-Oxo-7, 8-dihydropyrido[2, 3-d]pyridazine-5-carboxylic acid, 7-phenyl-8-oxo-7, 8-dihydropyrido[2, 3-d]pyridazine-5-carboxylic acid, and their esters, amides and hydrazides were prepared. Alkaline hydrolysis of 7-phenyl-8-oxo-7, 8-dihydroprido[2, 3-d]pyridazine-5-carboxylates gave phenylhydrazone of 3-formylpicolinic acid and good yields of 3-(2 ...
Ikutoshi Matsuura +2 more
openaire +2 more sources
Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice. [PDF]
, 2012 Tauopathies are widespread neurodegenerative disorders characterised by the intracellular accumulation of hyperphosphorylated tau. Especially in Alzheimer's disease, pathological alterations in the retina are discussed as potential biomarkers to improve ...
Arzberger, Thomas +11 more
core +3 more sources