Results 61 to 70 of about 10,186 (207)

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

Chemistry – A European Journal, Volume 32, Issue 1, 2 January 2026.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Synthesis and antibacterial activity of some novel thieno[2,3-c]pyridazines using 3-amino-5-phenyl-2-ethoxycarbonylthieno[2,3-c]pyridazine as a starting material

, 2014
3-Amino-5-phenyl-2-ethoxycarbonylthieno[2,3-c]pyridazine ( 6 ) was prepared by reaction of 4-cyano-6-phenylpyridazine-3(2 H )-thione ( 4 ) with ethyl chloroacetate in the presence of sodium ethoxide. Hydrazinolysis of compound 6 yielded the corresponding
A. S. Al-Kamali, A. Al-Hazmi, M. Alhousami, Mokhtar A. Al-Masany   +3 more
semanticscholar   +1 more source

Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

مجلة بغداد للعلوم, 2013
A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3 ...
Baghdad Science Journal
doaj   +1 more source

Ultrasound-assisted green synthesis of pyrroles and pyridazines in water via three-component condensation reactions of arylglyoxals

, 2013
A green and efficient method for the preparation of 5-aryl-4-hydroxy-2-methyl-1H-pyrrole-3carboxylic acid esters and 6-aryl-3-methylpyridazine-4-carboxylic acid esters via threecomponent reaction of arylglyoxal hydrates with β-dicarbonyl compounds in the
B. Eftekhari‐Sis, Saleh Vahdati‐Khajeh   +1 more
semanticscholar   +1 more source

Development of novel antibiotics derived from pyridazine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies

Results in Chemistry
In light of the increasing antibiotic resistance, it is crucial to discover new antimicrobial medications. Pyridazines are frequently investigated in research for the development of new chemical entities with enhanced therapeutic properties.
Mouad Lahyaoui, Mouad Filali, Khadija Benamar, Riham Sghyar, Kawtar Fikri-Benbrahim, Amal Haoudi, Ahmed Mazzah, Souad El khattabi, El Mestafa El Hadrami, Youssef Kandri Rodi, Nada Kheira Sebbar   +10 more
doaj   +1 more source

Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

Green Chemistry Letters and Reviews, 2019
In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with ...
Anhar Abdel-Aziem, Huda Refaat Mahmoud Rashdan, Entesar Mohamed Ahmed, Sara N. Shabaan   +3 more
doaj   +1 more source

New Horizon and Advancements in Synthetic and Biological Applications of Active Methylene Acetonitrile: Mini-Review

Journal of Chemistry
Acetonitrile is generally used as an organic solvent and can also be used as a significant starting material via active methylene acetonitrile in organic synthesis.
Lavanya Nagamalla, Kavitha Kothireddy, Basavarajaiah Suliphuldevara Mathada, Sharanagouda J. Patil, Lavanya Lakshminarayana   +4 more
doaj   +1 more source

New potential HEDMs with a pyridazine core: Structural modeling and assessment of thermochemical properties

FirePhysChem
The results of modeling the structure of compounds 2,4,7,9-tetranitrobenzo[c]cinnoline (1) and 1,2,3,4-tetrazino[5,6-f]pyridazino-1,2,3,4-tetrazine 1,3,7,9-tetra-N-oxides (2) containing a pyridazine core are presented.
D.V. Khakimov, T.S. Pivina
doaj   +1 more source

Pyridazines. VII. Synthesis of Cyanopyridazines.

Chemical and Pharmaceutical Bulletin, 1963
3-Chloro, 3-methyl, 3-methoxy, 3-benzyloxy, and 3-phenyl-6-cyanopyridazine (III, VI, X, XII, XIV) was synthesized from 3-chloro, 3-methyl, 3-methoxy, 3-benzyloxy, and 3-phenylpyridazine 1-oxide (II, V, IX, XI, XIII).
openaire   +3 more sources