Results 151 to 160 of about 148,723 (205)

Nicotinonitriles-based therapeutics as versatile pharmacophores in rational anticancer drug design. [PDF]

RSC Adv
Nafie MS, Zeidan MA, Fahmy SA, Diab MK, Darwish KM, Yassen ASA.   +5 more
europepmc   +1 more source

Discovery of New Pyrazole-Linked Pyridine Derivatives as Multi-Target Anti-Inflammatory Agents With Immunomodulatory Potential. [PDF]

Drug Dev Res
Salem MA, Raslan RR, Gohar NA, Abusaif MS, Ammar YA, Ragab A.   +5 more
europepmc   +1 more source

Gold Single‐Atom Catalysts Enable Selective Shuttle Hydrochlorination of Alkynes

Angewandte Chemie International Edition, EarlyView.
Gold single‐atom catalysts on activated carbon enable heterogeneous shuttle hydrochlorination of terminal alkynes to vinyl chlorides with high chemo‐ and stereo‐selectivity thanks to cooperation between Au(I) sites and the support. The catalytic system combines broad substrate compatibility, simplified separation, and recoverability, paving the way for
Marc‐Eduard Usteri, Eva J. Meeus, Christian Zachau, Seung‐Eun Choi, Aram Bugaev, Milivoj Plodinec, Sharon Mitchell, Bill Morandi, Javier Pérez‐Ramírez   +8 more
wiley   +1 more source

Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance. [PDF]

Sci Adv
Smith LL, Warren WS.
europepmc   +1 more source

Emerging Strategies for <i>meta</i>-Heteroatom Functionalization of Pyridines. [PDF]

JACS Au
Francisco TN, Silva AMS, Albuquerque HMT.   +2 more
europepmc   +1 more source

Thinking Outside the Binding Site: A Self‐Encapsulating Kinase Inhibitor Remodels Its Pocket to Achieve Selectivity

Angewandte Chemie International Edition, EarlyView.
To make exceptionally effective drugs, thinking “outside the binding site” is required. This work reveals that counterintuitive targeting of a kinase‐conserved region can lead to highly selective binding. Inhibitor discovery coupled to x‐ray crystallography shows that a network of noncanonical interactions and long‐range effects of distant unique amino
Nico J. Seidler, Monica R. MacDonald, Athina A. Moschopoulou, Sahba Cunningham, Tess M. Weber, Nader N. Nasief, Lorenz Mayer, Frederik W. Hacker, Ekaterina Hermann, Mareike B. Möllers, Yuliia Skliarenko, Tahereh Damghani, Abid N. Manzar, Kaly S. Lin, Ramona Rudalska, Marcia I. Goettert, Lars Zender, Daniel Dauch, Michael Forster, Stefan A. Laufer, David E. Heppner   +20 more
wiley   +1 more source

Surface Ligand Composition of Polyoxovanadate-Alkoxides Influences Hole Transfer from CdSe Quantum Dots. [PDF]

Inorg Chem
M Peter CY, Hancock B, Caruso JJ, Flemings NB, Hintz MC, Krauss TD, Matson EM.   +6 more
europepmc   +1 more source

Near Infrared Photoswitching by Direct Excitation—A Next Frontier

Angewandte Chemie International Edition, EarlyView.
Molecular photoswitches finally enter the spectral realm of near‐infrared for their direct excitation. This minireview summarizes the current state‐of‐the‐art, the design principles for achieving such low‐energy light responsiveness, and the unique applications that are unlocked by it.
Diptiprava Sahoo, Elias Ciekalski, Henry Dube   +2 more
wiley   +1 more source