Results 171 to 180 of about 344,103 (291)

Stereoselective Biotransformation: Transfer of Learning to Advance Drug Metabolism and Biocatalysis

Angewandte Chemie, EarlyView.
Understanding stereoselective biotransformations has implications for predicting drug disposition and response and may also inspire novel biocatalytic and biomimetic strategies to address challenges in metabolite and API synthesis. ABSTRACT Chirality is an important determinant of drug action, as enantiomers can exhibit markedly different ...
Grace A. Okunlola, Godwin A. Aleku
wiley   +2 more sources

Synthesis and Biological Evaluation of Imidazopyridine-Isatin Hybrids as Inhibitors of <i>Leishmania major</i> Growth. [PDF]

Drug Des Devel Ther
El Hassab MA, Eldehna WM, Elsayed ZM, Elbadawi MM, Negmeldin AT, Balaha M, Nasralla SN, Monir R, Ibrahim TM, Abe M, Tawfik HO, Bekhit AA, Hemeda LR.   +12 more
europepmc   +1 more source

Nickel‐Catalyzed Enantioconvergent Arylation of Unactivated Cyclic Electrophiles: Asymmetric Synthesis of 3‐Substituted Pyrrolidines

Angewandte Chemie, EarlyView.
Metal‐catalyzed enantioconvergent substitutions of unactivated cyclic electrophiles by organometallic nucleophiles have not previously been reported. Herein, a chiral nickel catalyst is described that achieves this objective, coupling 3‐iodopyrrolidine derivatives with arylzinc nucleophiles.
Ting Hei Matthew Wong, Xiaoyu Tong, Gregory C. Fu   +2 more
wiley   +2 more sources

Pyridine Into Pyrrole Transformation Induced Within the Confinement of the Macrocycle. [PDF]

Angew Chem Int Ed Engl
Krzyszowska P, Burska-Jabłońska A, Oberski M, Białek MJ, Latos-Grażyński L, Hurej K.   +5 more
europepmc   +1 more source

Radikale Kaskadenreaktion, welche die Kreuzkupplung von Olefinen mit der Smiles‐Truce‐Umlagerung kombiniert

Angewandte Chemie, EarlyView.
Wir stellen eine kobaltkatalysierte Radikalkaskade vor, die zwei Alken Ausgangsstoffe effizient miteinander verbindet und so in einem einzigen Schritt mehrere Bindungen aufbaut. Der Prozess beginnt mit einem kobaltkatalysierten Wasserstoffatomtransfer an eine Styrol‐Doppelbindung, gefolgt von einer Giese‐Addition.
Jingyang Qin, Lucas Popek, Moritz Wyrtki, Christopher J. Teskey   +3 more
wiley   +1 more source

Structurally Constrained Stibenium: Metallomimetic C−Si Bond Activation

Angewandte Chemie, EarlyView.
A structurally constrained stibenium cation supported by a 2,6‐bis(o‐carborano)pyridine pincer‐type ligand was prepared, and its preliminary reactivity toward silanes was investigated. Remarkably, Si−C bonds in silanes undergo activation via an oxidative‐addition‐type process at the cationic Sb center.
Donia Toami, Roman Dobrovetsky
wiley   +2 more sources

Pyridine

Journal of Synthetic Organic Chemistry, Japan, 1982
Meera Asthana, L.M. Mukherjee
openaire   +3 more sources

Substituent Effects Control the Biological Activity of Mn(II) Imidazo[1,2-a]pyridine Complexes. [PDF]

Molecules
Rydz M, Mazur T, Świtlicka A, Komarnicka UK, Wojtala D, Lesiów MK, Kyzioł A, Kędzierski P, Bieńko DC.   +8 more
europepmc   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, EarlyView.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

Synthesis of Avenanthramide C and Its Analogs Utilizing Classical Condensation, Saponification and Acidification. [PDF]

ACS Omega
Choi SM, An YJ, Nam YE, Kwon SJ, Choi ER, Cho JH.   +5 more
europepmc   +1 more source