Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases. [PDF]
Sharma M, Biegasiewicz KF.
europepmc +1 more source
Der peri‐benzo[a]fluoranthenthioindigo (PBFT) Photoschalter kann direkt durch Nahinfrarot‐Licht mit Wellenlängen bis zu 900 nm angeregt werden. Er bietet ein hochperformantes Eigenschaftsprofil mit kontrastreichen Farbänderungen zwischen blassgrün und tiefblau.
Elias Ciekalski, Henry Dube
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Synthesis and quantum chemical studies of polyfunctionally substituted pyridines incorporating pyrimidine moiety for corrosion Inhibition. [PDF]
Hussein AHM +4 more
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Speciation‐Controlled C–F Bond Functionalization Enabled by Zwitterionic Pnictinidenes
Zwitterionic pnictinidenes turn C–F activation into C–X bond construction, enabling broad defluorinative functionalization of polyfluoro(hetero)arenes under mild conditions. Rather than following a metallomimetic Sb(I)/Sb(III) redox turnover, catalysis is redirected by ligand scrambling into a redox‐neutral manifold, revealing catalyst speciation as a ...
Irene Sánchez‐Sordo +4 more
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Structural basis for high-affinity inhibitor binding to lipid kinases PIP4K2A and PIP4K2B. [PDF]
He Z +6 more
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Cyclopentadienes (CpHs) are fundamental building blocks with widespread applications in chemistry. However, their inherent acidity and isomeric instability have long limited access to chiral variants in an asymmetric fashion. Here, we introduce a CuH‐catalyzed asymmetric transformation that provides an unprecedented entry into a new class of ...
Piero Soppelsa +4 more
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Structure-Based Drug Discovery of Triazine Derivatives as Potent and Orally Bioavailable AXL Inhibitors for Cancer Therapy. [PDF]
Sun M, Wu S, Zhong Y, Xi N, Cao Q.
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Flavin Catalysts in Organic Synthesis
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
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Identification of an Orally Efficacious Imidazo[4,5-<i>c</i>]pyridine-6-Carboxamide Antimalarial with a High Barrier to Resistance. [PDF]
Zhou B +14 more
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We present here (1)⊂MIP‐216(Zr), a new hybrid material composed of an FeII spin crossover complex (1) loaded in the pores of a new hydrophobic metal–organic framework (MIP‐216(Zr), that presents a high affinity toward acetic acid and acts as a highly sensitive colorimetric sensor of acetic acid vapor due to a spin state switching of the encapsulated ...
Emmelyne Cuza +8 more
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