Results 211 to 220 of about 340,813 (275)

Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors

Angewandte Chemie, EarlyView.
We report a photoenzymatic hydroalkylation that enables streamlined, stereocontrolled access to aryl glutarimide precursors relevant to targeted protein degradation. Engineered flavin‐dependent “ene”‐reductases provide broad scope and high enantioselectivity through a distinct electron transfer–enantioselective proton transfer pathway.
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster   +9 more
wiley   +2 more sources

Total synthesis of natural products based on hydrogenation of aromatic rings. [PDF]

Beilstein J Org Chem
Wu H, Qi X.
europepmc   +1 more source

Electrochemical C4 alkylation of pyridine derivatives: Enhanced regioselectivity via silane assistance. [PDF]

Sci Adv
Yang Z, Liu X, Chen YX, Gao Y, Xiao X, Maekawa H, Zhang T, Hao XQ, Song MP.   +8 more
europepmc   +1 more source

The Influence of Hydrazo and Azo Bonds on the Conformation of New 4-Methyl-3,5-dinitro-2-(2-phenylhydrazinyl)pyridine and Its Azo Derivative-Structural Properties, Vibrational Spectra and Quantum Chemical DFT Calculations. [PDF]

Int J Mol Sci
Michalski J, Kucharska E, Bryndal I, Dymińska L, Sąsiadek W, Pyra A, Lisiecki R, Ptak M, Hanuza J.   +8 more
europepmc   +1 more source

Enhancement of gemcitabine toxicity and specificity through PI3K/Akt/Nrf2 pathway inhibition in pancreatic cancer. [PDF]

Front Pharmacol
Chen YS, O'Hagan S, Day PJR.
europepmc   +1 more source

A Convenient, Safe, and Atom‐Economical Route to a Large Portfolio of Grubbs‐Type Catalysts for Olefin Metathesis via Four‐Coordinate Ruthenium Alkylidynes

Angewandte Chemie, EarlyView.
It may seem counterintuitive to first target a ruthenium alkylidyne when Grubbs‐type ruthenium carbene complexes are the actual goal. In the end, however, this tactic pays valuable dividends in terms of practicality, atom economy, flexibility as well as safety: the new route provides ready access to a large assortment of catalysts for alkene metathesis
Mingxu Cui, Alois Fürstner
wiley   +1 more source

Synthesis of Multisubstituted Pyridines by Heterocyclization of TosMIC Derivatives: Total Synthesis of Caerulomycins A and K. [PDF]

Org Lett
García-García JA, Aceña JL, García-García P, Sucunza D.   +3 more
europepmc   +1 more source

Pyridine [PDF]

The American Journal of the Medical Sciences, 1894
openaire   +1 more source

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, EarlyView.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +1 more source

The Heterocycle Isostere Explorer: A Computational Tool for the Discovery of Novel Aromatic Heterocyclic Isosteres. [PDF]

J Med Chem
Holland MTO, Sebastián-Pérez V, Bradley AR, Duarte F, Brennan PE.   +4 more
europepmc   +1 more source