Results 11 to 20 of about 205,200 (319)
Highly enantioselective catalytic synthesis of chiral pyridines
Nature Communications, 2017 Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral ...
Ravindra P. Jumde +3 more
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1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
Molecules, 2022 Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 ...
Ana Donaire-Arias +5 more
semanticscholar +1 more source
Halogenation of the 3-position of pyridines through Zincke imine intermediates
Science, 2022 Pyridine halogenation reactions are crucial for obtaining the vast array of derivatives required for drug and agrochemical development. However, despite more than a century of synthetic endeavors, halogenation processes that selectively functionalize the
Benjamin T. Boyle +4 more
semanticscholar +1 more source
Practical and Regioselective Synthesis of C-4-Alkylated Pyridines.
Journal of the American Chemical Society, 2021 The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chemistry, particularly from pyridine itself.
J. Choi +3 more
semanticscholar +1 more source
Advanced Synthesis and Catalysis, 2020 . While remarkable progress has recently been made for the direct C-H-functionalization of azines, its application is still limited by a lack of accessible functional groups (primarily carbon-based) and poor regioselectivity.
Dong Wang +4 more
semanticscholar +1 more source
2-Sulfonyl pyridines as tunable, cysteine-reactive electrophiles.
Journal of the American Chemical Society, 2020 The emerging use of covalent ligands as chemical probes and drugs would benefit from an expanded repertoire of cysteine-reactive electrophiles for efficient and diverse targeting of the proteome.
C. Zambaldo +14 more
semanticscholar +1 more source
Fast microwave-assisted oxidation of 1,4-dihydropyridines with FeCl 3.SiO 2 [PDF]
, 2005 Pyridine derivatives are easily obtained in high yields by microwave-promoted rapid oxidation of the corresponding 1,4-dihydropyridines with ferric chloride hexahydrate and silica gel under solvent-free ...
Alaee, E. +4 more
core +1 more source
Molecules, 2021 Recently, the development of nanocatalysts based on naturally occurring polysaccharides has received a lot of attention. Chitosan (CS), as a biodegradable and biocompatible polysaccharide, is considered to be an excellent template for the design of a ...
Khaled D. Khalil +4 more
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Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution. [PDF]
, 2014 We report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, a series of functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are ...
Fier, Patrick S, Hartwig, John F
core +3 more sources
Acta Crystallographica Section E Structure Reports Online, 2010 The non-H atoms of the title compound, C(6)H(8)N(2), lie in a common plane (r.m.s. deviation = 0.034 Å). In the crystal, adjacent mol-ecules are linked by inter-molecular N-H⋯N hydrogen bonds into a zigzag chain running along the c axis.
openaire +3 more sources