Results 131 to 140 of about 22,841 (254)

Direct C–H Sulfonylimination of Pyridinium Salts

A direct pyridinium C–H sulfonylimination has been developed for the synthesis of sulfonyl iminopyridine derivatives with high efficiency. This transformation features the direct and efficient formation of a CN bond with a high functional group ...
Rui Sun (177521), Juan Tang (437969), Xueli Zheng (284806), Maoling Yuan (11497657), Ruixiang Li (1666966), Wenjing Li (198063), Haiyan Fu (133503), Lihua Luo (3684442), Hua Chen (43790)   +8 more
core   +1 more source

Practical Enantioselective Approach to 3‐Amino‐2‐Hydroxy Acids and Application to the Synthesis of Natural Products

Chirality, Volume 38, Issue 7, July 2026.
A practical and straightforward approach to optically active erythro 3‐amino‐2‐hydroxy acids and its application to the enantioselective synthesis of 3‐phenylisoserine and of the marine natural product 3‐amino‐2‐hydroxy‐6‐methylheptanoic acid is reported.
Marilena Caporale, Giulia Marsico, Ernesto Santoro, Patrizia Scafato, Stefano Superchi   +4 more
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Radiolabeled Angiopep‐2 Peptide Vector as a Preclinical Platform for Blood–Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice

Journal of Peptide Science, Volume 32, Issue 7, July 2026.
The developed DOTA‐Angiopep‐2 conjugate was well tolerated in glioma cells and enabled high‐yield radiolabeling with 177Lu and 161Tb. The 161Tb conjugate showed brain delivery with predominantly renal clearance, supporting a stable radiotheranostic platform for BBB‐targeted glioma therapy and SPECT imaging.
Evgenia Fotou, Adamantia Apostolopoulou, Christina‐Georgia Bika, Maria Giannakopoulou, Danai‐Efraimia Bajwa, Vassilios Moussis, Vassilios Tsikaris, Ioannis P. Gerothanassis, George A. Alexiou, Penelope Bouziotis, Andreas G. Tzakos   +10 more
wiley   +1 more source

High‐Energy‐Density Redox Flow Batteries: Mechanisms, Design Strategies, and Recent Progress

Chemistry – A European Journal, Volume 32, Issue 24, 23 June 2026.
ABSTRACT The inherent intermittency of energy sources such as solar and wind power hinders the transition to renewable energy, necessitating advanced energy storage solutions. Enhancing energy density is crucial for lowering system costs and enabling large‐scale deployment.
Xiaolian Zhao, Jiaxin Yu, Nannan Jia, Chuzhang Hong, Yue Luo, Wantong Jing, Zhiming Feng, Xinhua Liu, Rui Tan   +8 more
wiley   +1 more source

Application of quinolinium and pyridinium salts for determination of selected sulfur compounds in biological samples

, 2014
Quinolinium and pyridinium salts belong to the group of onium compounds and are widely used in organic, structural and analytical chemistry. Their synthesis is mainly based on quaternization of the nitrogen atom in a heterocyclic ring [4, 13, 23].
Głowacki, R., Furmaniak, P., Wyszczelska-Rokiel, M., Kubalczyk, P.   +3 more
core  

Synthesis of 2‐Aza‐Bicyclo[4.3.0]nonane Derivatives Related to the Camporidines via Intramolecular [3+2]‐Cycloaddition

European Journal of Organic Chemistry, Volume 29, Issue 24, 23 June 2026.
The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher, Tobias Wilczek, Nora Katharina Korber, Jörg-Martin Neudörfl, Bernd Goldfuss, Hans-Günther Schmalz   +5 more
wiley   +1 more source

Site‐Selective Functionalization of Cysteine Units in Peptides Through Meerwein Arylation Reactions Under Mild Conditions

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
α‐Methylstyrenes are known as highly efficient scavengers for aryl radicals. Herein, a bifunctional reagent is introduced that merges a 2‐bromoacyl moiety for thiol coupling with a styrene unit for subsequent radical functionalization. The sequential transformations proceed under mild conditions, enabling selective cysteine modification in peptidic ...
Daniel R. Troeger, Nina Diesendorf, Ryan Thurston, Markus R. Heinrich   +3 more
wiley   +1 more source

Redox‐Active Guanidines

ChemElectroChem, Volume 13, Issue 12, 17 June 2026.
Redox‐active guanidines, comprising guanidino‐functionalized aromatics (GFAs) and redox‐active urea azines (RAAs), are electron donors and strong Lewis and Brønsted bases that are used in several applications. They act as redox‐active ligands in bistable coordination compounds and as reagents in dehydrogenative coupling reactions and proton‐coupled ...
Hans‐Jörg Himmel
wiley   +1 more source

Novel cinnamic acid-based <i>N</i>-benzyl pyridinium analogs: potent dual cholinesterase inhibitors with neuroprotective properties for Alzheimer's disease. [PDF]

RSC Adv
Esmkhani M, Mahdavi M, Javanshir S, Iraji A.   +3 more
europepmc   +1 more source