Results 91 to 100 of about 7,582 (216)

An overview of synthesis and biological activities of 2-pyridone derivatives over the last decade

Discover Applied Sciences
2-Pyridone frameworks are a pervasive member of the N-heterocyclic family of both chemical and therapeutic interest. 2-Pyridones and their bridged analogues have wide occurrences in nature and the presence of both aromatic and amide groups in the ...
Lopamudra Das, Tista Sengupta
doaj   +1 more source

SYNTHETIC ROUTES AND NATURAL SOURCES OF 2-PYRIDONE DERIVATIVES AND THEIR PHARMACOLOGICAL ACTIVITY

, 2017
Objective: 2-pyridone is a well-known heterocyclic ring having significant biological and medical application. The molecular structures and various activities of 2-pyridone derivatives as well as their syntheses and natural occurrence are analyzed and ...
MISHRA, PREM SHANKAR, V, Ravichandiran, M, Vijey Aanandhi   +2 more
core   +2 more sources

Combining the Ugi-azide multicomponent reaction and rhodium(III)-catalyzed annulation for the synthesis of tetrazole-isoquinolone/pyridone hybrids

Beilstein Journal of Organic Chemistry, 2019
An efficient sequence based on the Ugi-azide reaction and rhodium(III)-catalyzed intermolecular annulation has been established for the preparation of tetrazole-isoquinolone/pyridone hybrids.
Gerardo M. Ojeda, Prabhat Ranjan, Pavel Fedoseev, Lisandra Amable, Upendra K. Sharma, Daniel G. Rivera, Erik V. Van der Eycken   +6 more
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Charge Density Study of 2-Pyridone

, 1998
The crystal structure of 2-pyridone has been redetermined from high-resolution X-ray data collected at 123 K. The molecule is in the lactam form. Bond lengths (corrected for rigid-body libration) and angles have been determined with s.u.'s of 0.001 Å and
H. W. Yang, B. M. Craven
core   +1 more source

Total synthesis of (−)-epimyrtine by a gold-catalyzed hydroamination approach

Beilstein Journal of Organic Chemistry, 2013
A new approach to the total synthesis of (−)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization.
Thi Thanh Huyen Trinh, Khanh Hung Nguyen, Patricia de Aguiar Amaral, Nicolas Gouault   +3 more
doaj   +1 more source

The synthesis of 1-vinyl-2-pyridone

, 2012
Kim Dmitriy Gymnanovich – Dr. Sc. (Chemistry), Professor, Head of Organic Chemistry Subdepartment, Chemistry Department, South Ural State University. 76, Lenin avenue, Chelyabinsk, 454080.
Бердникова, Е. В., Berdnikova, E. V., Ким, Д. Г., Kim, D. G.   +3 more
core  

Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins

, 2017
A new type of porphyrin photosensitizer capable of generating singlet oxygen upon irradiation, storing it through binding to pyridone subunits, followed by slow release at 20‐40 °C is reported.
Flanagan, Keith J., Boyle, Ross W., Sitte, Elisabeth, Filatov, Mikhail A., Senge, Mathias, Savoie, Huguette, Callaghan, Susan   +6 more
core  

Direct and Regioselective Monofluorination of N‑Protected Pyridone Derivatives using N‑Fluorobenzenesulfonimide (NFSI)

, 2019
The direct monofluorination of N-protected pyridone derivatives has been developed using a stable electrophilic fluorinating reagent, N-fluorobenzenesulfonimide (NFSI).
Fumie Sakurai (5277413), Takahiko Taniguchi (713945), Fumie Sakurai, Takafumi Yukawa (2271727), Takafumi Yukawa, Takahiko Taniguchi   +5 more
core   +1 more source

Examining the safety of nicotinamide for skin cancer prevention: Review of adverse events, metabolism, and toxic dosages

JAAD Reviews
Nicotinamide (niacinamide) supplementation for non-melanoma skin cancer prevention has sparked controversy over the past decade due to its inconsistent evidence of chemoprevention and its recently challenged safety profile.
Katie R. Xu, BA, Micah Belzberg, MD, Allison T. Vidimos, MD, RPh   +2 more
doaj   +1 more source

Cocrystals composed of 4,4 '-(fluorene-9,9-diyl) diphenol and 6-methyl-2H-pyridone

, 2007
The crystal structures of two cocrystals composed of 4,40(uorene- 9,9-diyl)diphenol (C25H18O2) and 6-methyl-2H-pyridone (C6H7NO) are reported, namely 4,4'-(fluorene-9,9-diyl) diphenol-6-methyl-2H-pyridone (1/2), C(25)H(18)O(2)(.)2C(6)H(7)NO, (I), and 4,4'
Howard, J. A. K., Lavy, T., Meirovich, N., Sparkes, H. A., Kaftory, M.   +4 more
core   +1 more source