Results 1 to 10 of about 20,092 (323)
The Biochemical Pathways of Nicotinamide-Derived Pyridones [PDF]
International Journal of Molecular Sciences, 2021 As catabolites of nicotinamide possess physiological relevance, pyridones are often included in metabolomics measurements and associated with pathological outcomes in acute kidney injury (AKI). Pyridones are oxidation products of nicotinamide, its methylated form, and its ribosylated form.
Faisal Hayat +2 more
exaly +7 more sources
Diversity-oriented functionalization of 2-pyridones and uracils
Nature Communications, 2021 Diversity-oriented synthesis of 2-pyridone and uracil derivatives is in urgent need in medicinal chemistry as they are useful pharmacophores. Here the authors show that palladium/norbornene cooperative catalysis enabled dual-functionalization of ...
Hong-gang Cheng +2 more
exaly +3 more sources
2-Bromopyridines as Versatile Synthons for Heteroarylated 2-Pyridones via Ru(II)-Mediated Domino C–O/C–N/C–C Bond Formation Reactions [PDF]
MoleculesA novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na2CO3 catalytic system.
Miha Drev +6 more
doaj +2 more sources
Recent Progresses in the Catalytic Stereoselective Dearomatization of Pyridines [PDF]
Molecules, 2023 1,2- and 1,4-dihydropyridines and N-substituted 2-pyridones are very important structural motifs due to their synthetic versatility and vast presence in a variety of alkaloids and bioactive molecules.
Lucrezia Margherita Comparini +1 more
doaj +2 more sources
Microwave assisted synthesis of 2-pyridone and 2-pyridone based compounds [PDF]
Hemijska Industrija, 2014 2-Pyridones are important heterocyclic compounds that are widely used in medical chemistry, and their various derivatives have significant biological and medical applications.
Mijin Dušan Ž. +3 more
doaj +5 more sources
Metal-Free Cascade Formation of C–C and C–N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties [PDF]
MoleculesA straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C–C and C–N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This
Yao Tang +5 more
doaj +2 more sources
A microwave approach to the synthesis of certain 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones [PDF]
Journal of the Serbian Chemical Society, 2014 A study of the synthesis of 4-substituted phenyl-6-phenyl-3-cyano-2-pyridones from 2-cyano-3-phenylsubstituted acrylates and acetophenone is presented. 2-Pyridones were obtained using conventional as well as microwave synthesis using solvent and
Marinković Aleksandar +4 more
doaj +1 more source
Acta Chimica Slovenica, 2021 Manganese(II) bis(4,4,4-trifluoro-1-phenylbutane-1,3-dionate) complexes with pyridin-4-one (pyon), 3-hydroxypyridin-2-one (hpyon), 1-fluoropyridine (pyF) and methanol were prepared and the solid-state structures were determined by single-crystal X-ray ...
Anže Čavić, Franc Perdih
doaj +1 more source
Open Chemistry, 2021 The COVID-19 outbreak is a matter of concern worldwide due to unavailability of promising treatment comprising medication or vaccination till date. The discovery of antiviral drug is of immense importance in the existing spread of novel coronavirus.
Abdellatiif Magda H. +3 more
doaj +1 more source
Divergent rhodium-catalyzed electrochemical vinylic C–H annulation of acrylamides with alkynes
Nature Communications, 2021 α-Pyridones and α-pyrones are ubiquitous structural motifs found in natural products and components of biologically active small molecules. Here, the authors report an oxidant-free Rh-catalyzed electrochemical divergent vinylic C–H annulation of ...
Yi-Kang Xing +6 more
doaj +1 more source