Results 211 to 220 of about 16,008 (266)

DFT/B3-LYP study of the hydrogen-bonding cooperativity: application to (2-pyridone)2, 2-pyridone–H2O, 2-pyridone–CH3OH and 2-pyridone–CH3OCH3

Chemical Physics Letters, 2000
Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
R. Ramaekers, Ahmed Dkhissi, Ahmed Dkhissi, Guido Maes, Ludwik Adamowicz, Linda Houben   +5 more
openaire   +2 more sources

Metal-free regioselective direct thiolation of 2-pyridones.

Organic and biomolecular chemistry, 2019
A highly regioselective metal-free direct C-H thiolation of 2-pyridones with disulfides or thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2 enables the successful direct ...
Kunita Phakdeeyothin, Sirilata Yotphan
semanticscholar   +1 more source

Ru(II)-Catalyzed C6-selective C–H amidation of 2-pyridones

, 2018
Ru(II)-Catalyzed C6 site-selective amidation of 2-pyridones with 1,4,2-dioxazol-5-ones has been developed. The reaction occurred with a low catalyst loading and broad substrate scope under mild conditions, affording desired products in up to 98% yields ...
Lei Zhang, Xiangyun Zheng, Jinkang Chen, K. Cheng, Licheng Jin, Xinpeng Jiang, Chuanming Yu   +6 more
semanticscholar   +1 more source

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones.

Organic Letters, 2019
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity.
Pardeep Singh, Andrew G. Cairns, Dan E Adolfsson, Jörgen Ådén, U. Sauer, F. Almqvist   +5 more
semanticscholar   +1 more source

Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones.

Journal of Medicinal Chemistry, 2018
Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs ...
J. M. Bueno, Félix Calderón, J. Chicharro, J. C. de la Rosa, Beatriz Díaz, J. Fernández, J. Fiandor, M. T. Fraile, Mercedes García, E. Herreros, Adolfo G Garcia-Pérez, Milagros Lorenzo, A. Mallo, M. Puente, A. Saadeddin, S. Ferrer, Iñigo Angulo-Barturen, J. Burrows, María L León   +18 more
semanticscholar   +1 more source

Efficient Synthesis of N-Alkylated 4-Pyridones by Copper-Catalyzed Intermolecular Asymmetric Propargylic Amination.

Chemistry - An Asian Journal, 2018
Copper-catalyzed intermolecular asymmetric propargylic amination with 4-hydroxypyridines has been realized for the first time. In the presence of Cu complex derived from Pybox ligand, the N-propargylated 4-pyridones were obtained under mild reaction ...
W. Shao, Ye Wang, Ze-Peng Yang, Xiao Zhang, S. You   +4 more
semanticscholar   +1 more source

Pyridones in drug discovery: recent advances.

Bioorganic & Medicinal Chemistry Letters, 2021
Y. Zhang, A. Pike
semanticscholar   +1 more source

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

Synthesis, 2018
An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones
Xiao-Hua Li, Ai-Hui Ye, Cui Liang, Dong‐Liang Mo   +3 more
semanticscholar   +1 more source

Synthesis of 2,3-Dihydro-4-pyridones and 4-Pyridones by the Cyclization Reaction of Ester-Tethered Enaminones

The Journal of Organic Chemistry, 2020
2,3-Dihydro-4-pyridone skeleton is an important building block in organic synthesis because it features several reaction sites with nucleophilic or electrophilic properties. Herein, we disclose a method for its formation by intramolecular cyclization of ester-tethered enaminones, which can easily be synthesized from readily available materials, such as
Milovan Stojanović, Slobodan Bugarski, Marija Baranac-Stojanović   +2 more
openaire   +4 more sources

Umpolung-like Cross-coupling of Tosylhydrazones with 4-Hydroxy-2-pyridones under Palladium Catalysis.

Organic Letters, 2019
Tosylhydrazones under palladium catalysis were found to perform cross-coupling reactions with 4-hydroxy-2-pyridones. The umpolung-like reactivity, between the α-carbon of tosylhydrazone and the 3-position of the heterocycle, which is observed in the ...
Tania Katsina, K. C. Papoulidou, A. Zografos   +2 more
semanticscholar   +1 more source