Results 221 to 230 of about 20,827 (302)

BRAF inhibitor or BRAF/MEK inhibitor treatment for patients with metastatic BRAF V600E mutated differentiated thyroid cancer. [PDF]

open access: yesArch Endocrinol Metab
Finkel I   +9 more
europepmc   +1 more source

A model-based comparison of dose reduction strategies for fixed-dose dolutegravir-containing regimens. [PDF]

open access: yesJ Antimicrob Chemother
Dickinson L   +7 more
europepmc   +1 more source

Ruthenium(II)-Catalyzed Remote C-H Sulfonylation of 2-Pyridones.

Organic Letters, 2023
Herein, a ruthenium-mediated remote C-H mono- and disulfonylation of 2-pyridones with arylsulfonyl chlorides is developed. The catalytic system consisting of a [Ru(p-cymene)Cl2]2 catalyst and KOAc additive allows 2-pyridones to undergo C3,C5 ...
Fengqi Yang   +6 more
semanticscholar   +1 more source

Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylides.

Organic Letters, 2021
A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones has been developed, affording N-alkylated 2-pyridone derivatives in good yields and excellent N-selectivity.
Xiaofeng Liu, Y. Shao, Jiangtao Sun
semanticscholar   +1 more source

Bioevaluation of synthetic pyridones as dual inhibitors of α‐amylase and α‐glucosidase enzymes and potential antioxidants

Archiv der Pharmazie, 2022
Herein, a library of novel pyridone derivatives 1–34 was designed, synthesized, and evaluated for α‐amylase and α‐glucosidase inhibitory as well as antioxidant activities.
F. Saleem   +11 more
semanticscholar   +1 more source

Synthesis of N-Substituted 3-Amino-2-pyridones.

Organic Letters, 2022
Pyridones are versatile building blocks in organic synthesis and a privileged motif in drug discovery. However, N-substituted 2-pyridones bearing an α-tertiary carbon, cyclopropyl, or heterocycle off of the pyridone nitrogen atom remain challenging to ...
Philippe N Bolduc   +4 more
semanticscholar   +1 more source

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