Results 231 to 240 of about 20,827 (302)

Cobalt(III)-Catalyzed Regioselective C6 Olefination of 2-Pyridones Using Alkynes: Olefination/Directing Group Migration and Olefination.

Organic Letters, 2021
Co(III)-catalyzed highly regio- and stereoselective direct C6 olefination of 2-pyridones with alkynes has been developed with the assistance of chelation.
Xin Xu, Lin Zhang, Haoqiang Zhao, Yixiao Pan, Jiajie Li, Zhenli Luo, Jiahong Han, Lijin Xu, Ming Lei   +8 more
semanticscholar   +1 more source

Chemo- and Enantioselective Insertion of Furyl Carbene into the N-H Bond of 2-Pyridones.

Angewandte Chemie, 2021
Asymmetric carbene insertion reactions represent one of the most important protocols to construct carbon-heteroatom bonds. The use of donor-acceptor diazo compounds bearing an ester group is however a prerequisite for achieving high enantioselectivity ...
Kai Wang, Zi‐Ye Liu, Guangyang Xu, Y. Shao, S. Tang, Ping-Fan Chen, Xinhao Zhang, Jiangtao Sun   +7 more
semanticscholar   +1 more source

Chemoselective N- and O-Difluoromethylation of 2-Pyridones, Isoquinolinones, and Quinolinones with TMSCF2Br.

Organic Letters, 2021
An operationally simple protocol for direct N- and O-difluoromethylation of 2-pyridones, quinolinones, and isoquinolinones using commercially available TMSCF2Br is disclosed. The chemoselectivity is modulated by simple variations in temperature, solvent,
Ziyue Zhu, V. Krishnamurti, Xanath Ispizua-Rodriguez, C. Barrett, G. Prakash   +4 more
semanticscholar   +1 more source

Copper-Catalyzed Regioselective Coupling of Tosylhydrazones and 2-Pyridones: A Strategy for the Production of N-Alkylated Compounds.

Journal of Organic Chemistry, 2021
The highly regioselective N-alkylation reaction of 2-pyridones was achieved through hydrazone chemistry, especially for substrates with bulky secondary alkyl groups.
Ye-bin Wu, Youzhi Wu, Jian Wu, Danqian Xu, Hui Jiang, Wenxu Chang, Chang-You Ma   +6 more
semanticscholar   +1 more source

Pd-Catalyzed Regio- and Enantioselective Aminoarylation of Allenols with Aryl Iodides and 2-Pyridones.

Organic Letters, 2021
A new asymmetric catalytic protocol for the synthesis of enantioenriched N-allyl 2-pyrodones has been developed via the first Pd-catalyzed regio- and enantioselective aminoarylation of allenols with aryl iodides and 2-pyridones.
Hongfang Li, Ijaz Khan, Mei‐ying Li, Zheng Wang, Xue‐Liang Wu, K. Ding, Y. Zhang   +6 more
semanticscholar   +1 more source

Ligand-Controlled Ni(0)–Al(III) Bimetal-Catalyzed C3–H Alkenylation of 2-Pyridones by Reversing Conventional Selectivity

, 2021
Conventional C–H alkenylation with alkynes via low-valent transition-metal catalysis occurs at the C6 or C4 position of 2-pyridone with electron-deficient C–H bonds.
Ge Yin, Yue Li, Rong-Hua Wang, Jiangting Li, Xuetao Xu, Yu-Xin Luan, Mengchun Ye   +6 more
semanticscholar   +1 more source

4-Hydroxy Pyridones from Heterologous Expression and Cultivation of the Native Host.

Journal of Natural Products, 2020
4-Hydroxy pyridones are a class of fungi-derived polyketide-nonribosomal peptide products featuring a core of 4-hydroxy-2-pyridone which have a wide range of biological activities.
Wei-Yang Zhang, Yue Zhong, Yang Yu, Dan-feng Shi, Huiyun Huang, Xiao-Long Tang, Yongheng Wang, Guo-dong Chen, Hui-ping Zhang, Chenli Liu, Dan Hu, Hao Gao, X. Yao   +12 more
semanticscholar   +1 more source

Rh(I)-Catalyzed C6-Selective Decarbonylative Alkylation of 2-Pyridones with Alkyl Carboxylic Acids and Anhydrides.

Organic Letters, 2020
A Rh-catalyzed chelation-assisted C6-selective C-H activation/alkylation of 2-pyridones with readily available alkyl carboxylic acids or anhydrides is introduced. The reaction proceeds via substrate decarbonylation.
Haoqiang Zhao, Xin Xu, Haiyang Yu, Bohan Li, Xingyu Xu, Huanrong Li, Lijin Xu, Q. Fan, P. Walsh   +8 more
semanticscholar   +1 more source

Tetrachlorobis(2-pyridone)-bis(μ2-2-pyridone)-dicopper

Acta Crystallographica Section C Crystal Structure Communications, 1993
In this structure two Cu II centres 3.4448 (11) A apart are bridged asymmetrically by two 2-pyridone ligands and each is further coordinated by three terminal ligands (two chlorides and one 2-pyridone). Each molecule has an approximate, non-crystallographic centre of symmetry.
A. J. Blake, R. E. P. Winpenny
openaire   +1 more source

Pyridones as Potential Antitumor Agents II: 4-Pyridones and Bioisosteres of 3-Acetoxy-2-pyridone

Journal of Pharmaceutical Sciences, 1980
Pyridone structural requirements for activity against murine P-388 leukemia have been extended to isosteric analogs of 3-hydroxy-4-pyridone, a compound previously found to have activity. An amino group can be substituted for the 3-hydroxyl function with retention of activity.
D R, Hwang, G R, Proctor, J S, Driscoll
openaire   +2 more sources