Results 251 to 260 of about 20,827 (302)

Rhodium(III)-Catalyzed C(sp2)-H Functionalization of Cyclobutenes. Access to Cyclobuta[c]pyridones and -pyridines.

Organic Letters, 2019
O-(ω-Alkynyl) hydroxamates derived from cyclobutenyl carboxylic acids were identified as viable substrates in intramolecular rhodium(III)-catalyzed heteroannulations, which led to diversely substituted cyclobuta[c]pyridones.
Tomas J. Saiegh, Henri Chédotal, C. Meyer, J. Cossy   +3 more
semanticscholar   +1 more source

DFT/B3-LYP study of the hydrogen-bonding cooperativity: application to (2-pyridone)2, 2-pyridone–H2O, 2-pyridone–CH3OH and 2-pyridone–CH3OCH3

Chemical Physics Letters, 2000
Abstract DFT/B3-LYP(6-31++G**) calculations are used to provide information on closed N – H ⋯ O H -bonded complexes, containing two hydrogen bonds. The studied model systems with two H-bonds are the 2-pyridone dimer, 2-pyridone–H2O and 2-pyridone–CH3OH.
A. Dkhissi, R. Ramaekers, L. Houben, L. Adamowicz, G. Maes   +4 more
openaire   +1 more source

Pyridone photoelectrocyclizations to pyridophenanthrenes

Tetrahedron, 2017
Abstract This article describes the synthesis of pyridophenanthrenes from the stereoselective electrocyclization and [1,5]-hydride shift sequences of biphenyl pyridones. The regioselectivity of the reaction of meta-substituted biphenyl substrates depended on the electronic environment of the substituents.
Xuchen Zhao, Jon D. Rainier
openaire   +1 more source

Metal-free regioselective direct thiolation of 2-pyridones.

Organic and biomolecular chemistry, 2019
A highly regioselective metal-free direct C-H thiolation of 2-pyridones with disulfides or thiols has been developed. A combination of persulfate and a commercially available halide source such as LiCl, NCS or I2 enables the successful direct ...
Kunita Phakdeeyothin, Sirilata Yotphan
semanticscholar   +1 more source

Pyridones in drug discovery: recent advances.

Bioorganic & Medicinal Chemistry Letters, 2021
Y. Zhang, A. Pike
semanticscholar   +1 more source

A score years' update in the synthesis and biological evaluation of medicinally important 2-pyridones.

European journal of medicinal chemistry, 2022
Sarita Sangwan, N. Yadav, Ravi Kumar, Sonu Chauhan, V. Dhanda, Pooja Walia, A. Duhan   +6 more
semanticscholar   +1 more source

Synthetic Entries to Substituted Bicyclic Pyridones

Organic Letters, 2007
The synthesis of 6,6- and 5,6-bicyclic pyridone scaffolds has been completed using (i) an intramolecular Mitsunobu reaction and/or (ii) hydrolysis of a bicyclic pyridinium salt intermediate. Regioselective functionalization of the pyridone ring has been achieved via either direct lithiation or use of the "halogen dance" reaction.
Cheng, DC, Croft, LJ, Abdi, M (UG), Lightfoot, A, Gallagher, T   +4 more
openaire   +3 more sources

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones.

Organic Letters, 2019
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity.
Pardeep Singh, Andrew G. Cairns, Dan E Adolfsson, Jörgen Ådén, U. Sauer, F. Almqvist   +5 more
semanticscholar   +1 more source

Photochemical Reactivity of Pyridones

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Ring lithiation of pyridones

Journal of the Chemical Society, Perkin Transactions 1, 1988
Lithiation of 1-methyl-2-pyridone takes place mainly at the methyl group which then leads to a dimer (11) by addition to a second mol equivalent of pyridone at C-6. Lithiation of 1-methyl-4-pyridone takes place cleanly and efficiently at C-2; this lithio derivative gave a dimer (13) with a second mol equivalent of the pyridone and reacted with a ...
Premji Meghani, John A. Joule
openaire   +1 more source