Results 271 to 280 of about 20,092 (323)

Synthesis of Densely Functionalized N-Alkenyl 2-Pyridones via Benzyne-Induced Ring Opening of Thiazolino-Fused 2-Pyridones.

Organic Letters, 2019
We report the synthesis of 6-arylthio-substituted-N-alkenyl 2-pyridones by ring opening of bicyclic thiazolino-2-pyridones with arynes. Varied functionalization was used to investigate scope and substituent influences on reactivity.
Pardeep Singh, Andrew G. Cairns, Dan E Adolfsson, Jörgen Ådén, U. Sauer, F. Almqvist   +5 more
semanticscholar   +1 more source

Synthesis of 2,3-Dihydro-4-pyridones and 4-Pyridones by the Cyclization Reaction of Ester-Tethered Enaminones

The Journal of Organic Chemistry, 2020
2,3-Dihydro-4-pyridone skeleton is an important building block in organic synthesis because it features several reaction sites with nucleophilic or electrophilic properties. Herein, we disclose a method for its formation by intramolecular cyclization of ester-tethered enaminones, which can easily be synthesized from readily available materials, such as
Milovan Stojanović, Slobodan Bugarski, Marija Baranac-Stojanović   +2 more
openaire   +4 more sources

A score years' update in the synthesis and biological evaluation of medicinally important 2-pyridones.

European journal of medicinal chemistry, 2022
Sarita Sangwan, N. Yadav, Ravi Kumar, Sonu Chauhan, V. Dhanda, Pooja Walia, A. Duhan   +6 more
semanticscholar   +1 more source

Synthesis and Structure-Activity Relationships of the Novel Antimalarials 5-Pyridinyl-4(1 H)-Pyridones.

Journal of Medicinal Chemistry, 2018
Malaria is still one of the most prevalent parasitic infections in the world, with half of the world's population at risk for malaria. The effectiveness of current antimalarial therapies, even that of the most recent class of antimalarial drugs ...
J. M. Bueno, Félix Calderón, J. Chicharro, J. C. de la Rosa, Beatriz Díaz, J. Fernández, J. Fiandor, M. T. Fraile, Mercedes García, E. Herreros, Adolfo G Garcia-Pérez, Milagros Lorenzo, A. Mallo, M. Puente, A. Saadeddin, S. Ferrer, Iñigo Angulo-Barturen, J. Burrows, María L León   +18 more
semanticscholar   +1 more source

Efficient Synthesis of N-Alkylated 4-Pyridones by Copper-Catalyzed Intermolecular Asymmetric Propargylic Amination.

Chemistry - An Asian Journal, 2018
Copper-catalyzed intermolecular asymmetric propargylic amination with 4-hydroxypyridines has been realized for the first time. In the presence of Cu complex derived from Pybox ligand, the N-propargylated 4-pyridones were obtained under mild reaction ...
W. Shao, Ye Wang, Ze-Peng Yang, Xiao Zhang, S. You   +4 more
semanticscholar   +1 more source

Pyridones in drug discovery: recent advances.

Bioorganic & Medicinal Chemistry Letters, 2021
Y. Zhang, A. Pike
semanticscholar   +1 more source

Umpolung-like Cross-coupling of Tosylhydrazones with 4-Hydroxy-2-pyridones under Palladium Catalysis.

Organic Letters, 2019
Tosylhydrazones under palladium catalysis were found to perform cross-coupling reactions with 4-hydroxy-2-pyridones. The umpolung-like reactivity, between the α-carbon of tosylhydrazone and the 3-position of the heterocycle, which is observed in the ...
Tania Katsina, K. C. Papoulidou, A. Zografos   +2 more
semanticscholar   +1 more source

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt To Synthesize the Indenopyridine Core of Haouamine.

Organic Letters, 2019
An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R3MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized
Tomasz J. Idzik, Aleksandra Borzyszkowska-Ledwig, Łukasz Struk, J. Sośnicki   +3 more
semanticscholar   +1 more source

Phototoxicity and photogenotoxicity of nine pyridone derivatives

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2003
Nine structurally related pyridone derivatives were assayed for photogenotoxicity and phototoxicity in the Ames test, the chromosomal aberration test in V79 cells and the neutral red uptake (NRU) test in 3T3 cells. All nine compounds absorb light to a comparable degree at wavelengths between 380 and 430 nm.
Stephan Kirchner, R. Jakob-Roetne, U. Widmer, David J. McGarvey, M. Potthast, Andrée-Anne Chételat, Elmar Gocke, M. Csato, Wolfgang Muster   +8 more
openaire   +3 more sources

A Mild Rhodium Catalyzed Direct Synthesis of Quinolones from Pyridones: Application in the Detection of Nitroaromatics.

Journal of Organic Chemistry, 2017
A rhodium catalyzed direct regioselective oxidative annulation by double C-H activation is described to synthesize highly substituted quinolones from pyridones. The reaction proceeds at mild conditions with broad scope and wide functional group tolerance.
Aniruddha Biswas, Dipanjan Giri, D. Das, Anurima De, S. Patra, R. Samanta   +5 more
semanticscholar   +1 more source