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New Pathway of Conversion of Pyridoxal to 4-Pyridoxic Acid
Enzyme, 1976The only enzyme demonstrated so far to catalyze the formation of 4-pyridoxic acid, the final excretory product of vitamin B6, was aldehyde oxidase. In this paper we have presented an evidence that another enzyme, NAD+-dependent aldehyde dehydrogenase, is capable of catalyzing this reaction.
M Stanulović +3 more
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The triplet state of pyridoxal
Biochemical and Biophysical Research Communications, 1968Abstract The absorption spectra, as well as the relative distribution of the structures of pyridoxal in aqueous solution, have been investigated in several laboratories ( Williams and Neilands, 1954 ; Metzler and Snell, 1955 ; Anderson and Martell, 1964) .
Jorge E. Churchich, John E. Wampler
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Clinica Chimica Acta, 2017
We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed.
Tomoyuki Akiyama +7 more
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We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed.
Tomoyuki Akiyama +7 more
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Reaction of dithionite and bisulfite with pyridoxal and pyridoxal enzymes
Analytical Biochemistry, 1969Abstract Both bisulfite and dithionite produce marked changes in the spectra of pyridoxal, pyridoxal phosphate, and pyridoxal phosphate enzymes. The spectrum of pyridoxal phosphate in bisulfite solutions resembles that of the addition product of pyridoxal phosphate with cysteine.
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Direct polarographic determination of pyridoxal in the presence of pyridoxal-5-phosphate
Collection of Czechoslovak Chemical Communications, 1962The determination of pyridoxal in the presence of pyridoxal-5-phosphate may be1 based on the difference between the total wave-height obtained at pH about 9, where both substances give a diffusion-controlled wave and that obtained in acid media, where pyridoxal alone shows a kinetic current2.
O. Manoušek, Petr Zuman
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Pyridoxal-specific antibodies obtained with a synthetic pyridoxal-polypeptide conjugate
Biochimica et Biophysica Acta (BBA) - General Subjects, 1966Abstract The attachment of pyridoxal to a non-antigenic synthetic branched polypeptide resulted in an immunogenic macromolecule, capable of eliciting in rabbits antibodies with specificity directed against the pyridoxal moiety. The anti-pyridoxal antibodies were purified immunospecifically, making use of ion-exchange chromatography in 8 M urea.
Michael Sela, Hana Ungar‐Waron
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Pyridoxal Derivatives in Transamination
Nature, 1952IN living systems a transfer of amino groups occurs between certain amino-acids and keto-acids. This important reversible process, known as ‘transamination’1, effects a link between carbohydrate and protein metabolism, and the responsible enzymes, the transaminases, are activated by pyridoxal2 or pyridoxamine phosphates3. The proposed mechanisms of the
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Luminescence spectroscopy of pyridoxic acid and pyridoxic acid bound to proteins
European Journal of Biochemistry, 1994Luminescence techniques, i.e. fluorescence and phosphorescence, have been employed to study pyridoxic acid bound to proteins through a stable amide linkage. Proteins tagged with 4‐pyridoxic acid display the following fluorescence properties: (a) emission and excitation spectra centered at around 430 and 320 nm, respectively; (b) fluorescence quantum ...
Jorge E. Churchich +2 more
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Neuroprotective Effects of Pyridoxal Phosphate and Pyridoxal against Ischemia in Monkeys
Nutritional Neuroscience, 2001Previously, in monkeys undergoing 20 min whole brain ischemia we demonstrated that the activated calpain-induced lysosomal disruption with the resultant leakage of cathepsins B and L, causes neuronal death in the cornu Ammonis (CA) 1 sector on day 5.
Anton B. Tonchev +4 more
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Pyridoxal-5′-phosphate and pyridoxal biokinetics in aging Wistar rats
Experimental Gerontology, 1991Biokinetic parameters of plasma pyridoxal-5'-phosphate (PLP) and pyridoxal (PL) disposition were studied in male Wistar rats aged 8 and 27 months kept from weaning on a purified diet containing 250 g casein and 6 mg pyridoxine.HCl per kg. Baseline plasma PLP concentration was lower in the older animals (514 +/- 56 nmol/L for young and 317 +/- 124 nmol ...
Henk van den Berg, W. Bode
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