Results 141 to 150 of about 38,311 (239)

Divergent skeletal muscle metabolite exchange in insulin‐like growth factor‐1‐stimulated myotubes and resistance‐exercised human muscle

Experimental Physiology, Volume 111, Issue 8, Page 3784-3799, 1 August 2026.
Abstract Skeletal muscle hypertrophy requires a substantial nutrient influx for biomass accretion, but global metabolite exchange during growth is poorly characterized. Therefore, we profiled the metabolite uptake and release in insulin‐like growth factor‐1 (IGF‐1)‐stimulated C2C12 myotubes and human muscle 24 h after resistance exercise ...
Tim Havers, Moritz Eggelbusch, Marius Meinhold, Kira Sing, Rainer Okrojek, Anna Artati, Michael Witting, Dominik Lutter, Claire V. Kieker, Collin Starke, Tushar More, Karsten Hiller, Flemming Dela, Martin Schönfelder, André Kafka, Stephan Geisler, Henning Wackerhage   +16 more
wiley   +1 more source

A randomized Phase 1b trial evaluating the pharmacodynamics of ilofotase alfa in adults with hypophosphatasia. [PDF]

J Bone Miner Res
Seefried L, Bernholz J, Kraan M, Nitschke Y, Rutsch F, Mallek M, Kleinert S, Genest F.   +7 more
europepmc   +1 more source

S‐Adenosyl‐d‐Methionine as a Non‐Physiological Substrate for a Wide Range of SAM‐Dependent Enzymes

ChemBioChem, Volume 27, Issue 14, 29 July 2026.
From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Philipp Germer, Lukas Gericke, Lars‐Hendrik Koeppl, Ziruo Zou, Emely Jockmann, Marco Kuge, Katrin Zoller, Hannah Herrmann, Ronja Fuderer, Michael K. F. Mohr, Agnes Bartels, Göksu Oral, Peer Lukat, Gunhild Layer, Michael Müller, Wulf Blankenfeldt, Lena Barra, Jennifer N. Andexer   +17 more
wiley   +1 more source

From Fly to Human: Translational Relevance of <i>Drosophila</i> Models in the Study of Vitamin B6 and Cancer Relationship. [PDF]

Int J Mol Sci
Vernì F, Angioli C, Ferriero A, Agostini B.   +3 more
europepmc   +1 more source

Sustainable Synthesis of Bio‐Based Furanic and Aromatic Amines Using an Optimized Whole‐Cell Transaminase–Decarboxylase Cascade in E. coli RARE

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A whole‐cell biocatalytic cascade in engineered Escherichia coli RARE couples the ω‐transaminase from Pseudomonas psychrotolerans with pyruvate decarboxylase from Zymomonas mobilis to shift transamination toward amine formation via pyruvate removal. Integration of the cascade into a chemo‐enzymatic synthesis pathway enables the scalable production of 2,
Laura Edit Barabás, Róbert Tőtős, Tímea Éva Csete, Raluca Bianca Tomoiagă, Monica Ioana Toşa, Csaba Paizs   +5 more
wiley   +1 more source

Prescribing trends and clinical impact of calcium salt supplements in musculoskeletal pain: evidence from a multi-center retrospective analysis in India (TRACE study). [PDF]

BMC Musculoskelet Disord
Wani RJ, Kulkarni G, Nair R, Sharma V, Phani MV, Raju Y, Battacharya S, Shivane V.   +7 more
europepmc   +1 more source

Pyridoxal 5'-Phosphate-Dependent Enzymatic Decarboxylative Annulation. [PDF]

J Am Chem Soc
Chai W, Luo S, Xi W, He X, Zhang T, Zou Y, Hai Y.   +6 more
europepmc   +1 more source

Inhibition of pyridoxal kinase by the pyridoxal-gamma-aminobutyrate imine.

Journal of Biological Chemistry, 1980
D M, Abercrombie, D L, Martin
openaire   +2 more sources

Dietary Supplement Use Explains More Variance in Nutritional Biomarker Concentrations than 24-Hour Dietary Intake from Food Only: Evidence from a Cross-Sectional Survey of the United States Population (NHANES 2003-2006). [PDF]

Curr Dev Nutr
Sternberg MR, Pfeiffer CM, Powers CD, Ahluwalia N, Hamner H, Wang A, Wambogo E, Gahche JJ, Juan W.   +8 more
europepmc   +1 more source

The gut microbiota and plasma metabolites on functional dyspepsia: a study integrating Mendelian randomization and experimental validation. [PDF]

Front Med (Lausanne)
Hu X, Zhang X, Yang C, Chen L, Yang R, Wang C, Wu S, Ma L, Jiang W, Deng P, Su X, Wei W.   +11 more
europepmc   +1 more source