The Landscape of Cancer Metabolism as a Therapeutic Target
Pathology International, EarlyView.ABSTRACT Cancer cells reprogram their metabolism during progression to adapt to the tumor microenvironment, which is characterized by distinct differences in nutrient availability, oxygen concentrations, and acidity. This metabolic reprogramming can simultaneously create metabolic vulnerabilities unique to cancer cells, making cancer metabolism a ...
Kenji Ohshima
wiley +1 more source
A PHOSPHORYLATED DERIVATIVE OF PYRIDOXAL AS THE COENZYME OF TYROSINE DECARBOXYLASE
, 1944 I. C. Gunsalus +2 more
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The participation of pyridoxal phosphate, carnosine and calcium in the reversal of contraction in muscle fiber systems [PDF]
, 1963 Dugald E. S. Brown +2 more
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An eye on long‐duration spaceflight: Controversies, countermeasures and challenges
Experimental Physiology, EarlyView.Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng +1 more
wiley +1 more source
Red cell aspartate aminotransferase saturation with oral pyridoxine intake
São Paulo Medical JournalCONTEXT AND OBJECTIVE: The coenzyme of aspartate aminotransferase is pyridoxal phosphate, generated from fresh vegetables containing pyridoxine. Vitamin B6-responsive sideroblastic anemia, myelofibrosis and Peyronie’s syndrome respond to high pyridoxine ...
Marilena Oshiro +3 more
doaj +1 more source
PYRIDOXAL KINASE OF HUMAN BRAIN AND ITS INHIBITION BY HYDRAZINE DERIVATIVES
, 1959 Donald B. McCormick, Esmond E. Snell
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Polarographic study of the reaction of pyridoxal with hydroxylamine [PDF]
, 1964 P. Zuman, O. Manoušek
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Prenatal Brain Abnormalities in Sodium‐Dependent Multivitamin Transporter Deficiency
American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.ABSTRACT In treatable neurometabolic disorders, early diagnosis and prompt initiation of treatment are key to improved survival and outcomes. Biallelic variants in SLC5A6 cause sodium‐dependent multivitamin transporter deficiency (OMIM # 618973), which is treatable with high‐dose pantothenic acid, biotin, and alpha lipoic acid.
Eri Ogawa +2 more
wiley +1 more source
Structural insights into the orthosteric inhibition of P2X receptors by non-ATP analog antagonists
eLifeP2X receptors are extracellular ATP-gated ion channels that form homo- or heterotrimers and consist of seven subtypes. They are expressed in various tissues, including neuronal and nonneuronal cells, and play critical roles in physiological processes ...
Danqi Sheng +7 more
doaj +1 more source
Effect of an antiandrogenic H
, 1988 Because biochemical 'feminization' of the liver in males is observed with hepatic regeneration and because the hepatic regenerative response in females is greater than that in males, the posibility that antiandrogens might potentiate liver regeneration ...
Chapchap, P +7 more
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